银杏内酯注射液和胞磷胆碱钠片联合用于脑梗死恢复期患者治疗的有效性及安全性

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Efficacy and Safety the Combination Ginkgolide Injection and Citicoline Sodium Tablets in the Treatment Patients with Cerebral Infarction Convalescence Period/LIU Dan， CHEN Longwen， CHEN Junxuan.//MedicalInnovation ，2025，22（11）： 072-076

[Abstract]Objective： To explore the effcacy and safety Ginkgolide Injection combined with Citicoline SodiumTablets in thetreatment cerebral infarction convalescence period.Method： A total 108 cerebral infarction convalescence period patients admitted to Fengcheng People's Hospital from January 2022 to January 2024 were selected.They were divided into control group and observation group by random number table method， with 54 cases ineach group.The control group was treated with Citicoline SodiumTablets， andtheobservation group was treatedwith GinkgolideInjection combined with Citicoline Sodium Tablets.The clinicaleffcacy，neurological function，functionalrehabilitation status，serum inflammatory mediators，oxidative stress indexes and incidence adversereactions werecompared between the two groups.Result：The totalefective rate the observation group was higher than that the control group， the difference was statistically significant （ P <0.05）.After treatment， the national institutes health stroke scale （NIHSS）， modified Rankin scale （mRS） scores， C reactive protein （CRP）， interleukin-6（IL-6）and interleukin-8（IL-8）inthe observation groupwere lower than those in the control group， superoxide dismutase （SOD）was higher than that in control group，the diferences were statistically significant （ P <0.05）.There was no significant diference in the incidence adverse reactions between thetwo groups （ P >0.05）.

Conclusion：The treatment Ginkgolide Injection combined with Citicoline Sodium Tablets can promote the recovery nerve function，reducethe oxidativestressresponse，regulatethelevel inflammatory mediators，and improve the functionalrehabilitation patients inthe convalescent periodcerebralinfarction， withgood safety.

[Key words]Cerebral infarction convalescence periodGinkgolide Injection Citicoline Sodium Tablets Neurologicalfunction Safety

脑梗死是临床常见的急性脑血管疾病，患者主要症状为肢体麻木无力、头晕头痛、意识障碍等，恢复期患者因缺血部位血流动力学异常，易出现再灌注损伤，增加偏瘫、失语等后遗症发生率，危害患者身心健康[-2]。（剩余5361字）