经鼻高流量湿化氧疗联合布地奈德治疗急性呼吸衰竭患者的效果

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Effect of Nasal High-flow Humidification Oxygen Therapy Combined with Budesonide on Patients with Acute Respiratory Failure/FU Leiyu， HU Miaomiao， ZHANG Ting. //Medical Innovation of China， 2025，22（11）： 034-037

[Abstract]Objective： To investigate the effect of nasal high-flow humidification oxygen therapy combined with Budesonide Inhalation Aerosol on patients withacute respiratory failure.Method：Theclinical data of 72 patients with acute respiratory failure admitted to Xinyu Iron and Steel Group Co.， LTD.Central Hospital from July2021to July 2023 were retrospectivelyanalyzed.The patients were divided into different groups according to diffrent treatment methods.36 patients treated with Budesonide Inhalation Aerosol were used as control group， and 36 patients treated with Budesonide Inhalation Aerosol plus nasal high-flow humidification oxygen therapy were used asobservation group. Vital signs，oxygenation，respiratory dynamics， acute physiology and chronic health evaluation II （APACHEII） score and adverse reactions were compared between the two groups.Result： After treatment， the heart rate，diastolicblood pressure， systolic blood pressure， airway resistance，mean airway pressure， arterial partial pressure of carbon dioxide （PaCO）and APACHEII score in the observation group were lower than those in the control group， arterial partial pressure of oxygen （ ， oxygen saturation of blood ，oxygenation index （Ol） were higher than those of control group， the differences were statistically significant （ P <0.05）. There was no significant difference in the incidence of adverse reactions between the two groups （ P>0.05 ）. Conclusion： The application of nasal high-flow humidification oxygen therapy combined with Budesonide Inhalation Aerosol in the treatment of acute respiratory failure can improve the vital signs of patients， regulate the respiratory function and oxygenation status of the body， and have high safety.

[Key words] Acute respiratory failure Budesonide Inhalation AerosolNasal high-flow humidified oxygen therapyOxygenation indexAcute physiology and chronic health evaluation I score

急性呼吸衰竭是发病较急的呼吸功能障碍性疾病，以呼吸短促、发给、呼吸困难、昏迷等症状为表现，若短时间得不到治疗，机体无法进行有效的气体交换，可危及生命安全-2。（剩余5325字）