桂枝茯苓胶囊联合头孢曲松钠治疗子宫内膜炎的临床研究

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Clinical Study of Guizhi Fuling Capsules Combined with Ceftriaxone Sodium in the Treatment of Endometritis/TIAN Xing. //Medical Innovation of China， 2025， 22（11）： 057-061

[Abstract]Objective： To study the clinical effect of Guizhi Fuling Capsules combined with Ceftriaxone Sodiuminthe treatment ofpatients withendometritis.Method：This study was completedbyrandomizedcomparison method.70 patients with endometritis whowere admitted to the Obstetrics Department of Beijing Huairou Hospital from January 2020 to December 2023 were randomly divided into study group （n=35）and control group （n=35） by case random drawing method. The control group was treated with Ceftriaxone Sodium， while the study group was treatedwith Guizhi Fuling Capsules combined with Ceftriaxone Sodium.The clinical effect， duration of clinical symptom remisson， WHOQOL-BREF scores， levels of correlation factors and incidence of adverse reactions were comparedbetweenthetwo groups.Result：Theclinicaltotaleectiverateofthestudy groupwashigherthan thatof the control group， the difference was statistically significant （P<0.05） . The clinical symptom （lower abdominal pain，

① 北京怀柔医院产科北京101400通信作者：田星

lower abdominal distension，abnormal leucorrhea）remission times ofthe study groupwere earlier than those of the control group， the differences were statistically significant （ P<0.05） . After treatment， the WHOQOL-BREF scores of the study group werehigher than those of the control group，the diferences were statistically significant （ P <0.05）. After treatment， the levels of vascular endothelial growth factor （VEGF）， tumor necrosis factor- α （TNF -α ） hypoxia-inducible facton -1α （HIF- lα ），interleukin- 1β （IL- 1β ）in the study group were lower than those in the control group， the differences were statistically significant （ P <0.05）. There was no significant difference in the incidence of adverse reactions between the two groups （ P> 0.05）.Conclusion： Guizhi Fuling Capsules combined with Ceftriaxone Sodium can effectively treat endometritis，rapidlyrelieveclinical symptoms，improve quality of life， reduce inflammation， and be safe to use.

[Key words] Endometritis Guizhi Fuling Capsules Ceftriaxone Sodium

First-author's address： Department of Obstetrics， Beijing Huairou Hospital， Beijing 10140o， China doi： 10.3969/j.issn.1674-4985.2025.11.013

子宫内膜炎为生育期女性多发且常见的盆腔炎性病变，主要指支原体、衣原体、细菌等穿透子宫颈后侵人子宫内膜，引发局部炎症反应，患者主要临床症状为白带增多、下腹痛、月经或阴道分泌物异常等，部分重症患者伴有发热、头痛、寒战、食欲下降、心率加快等症状，此类症状反复发作，可导致患者生活质量显著降低-2]。（剩余5454字）