炎症相关分子及信号转导通路在慢性化脓性中耳炎中的研究进展

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[关键词］中耳炎，化脓性；细胞因子类；信号传导；分子靶向治疗；综述[中图分类号]R76 [文献标志码］A [文章编号] 2096-5532（2025）06-0940-04doi：10.11712/jms.2096-5532.2025.61.175 [开放科学（资源服务）标识码（OSID）][网络出版] https：//link.cnki.net/urlid/37.1517.R.20251218.0952.003; 2025-12-1917：11：58

Research advances ininflammatio-related molecules andsignal transductionpathways inchronic suppurative otitis mediaLOulai， LIN Yan，WANGRui，YIN Jiazhi，TANG Yong（DepartmentofOtolaryngology，Head and Neck Surgery，theFrst Affilia ted Hospital of Kunming Medical University，Kunming 65oooo，China）

[Abstract]Chronic suppurative otitis media（CSOM） is acommon ear diseasewithacomplex pathogenesis，and it is closely asociatedwiththeregulationof various inflammation-relatedmoleculesandsignaltransductionpathways.Recent studies have shownthatinflammatorygenes andinflammatoryfactors playakeyroleinthepathogenesisofCSOM，andtheabnormalexpres sionof inflammation-relatedmoleculesandchangesintheactivityofsignalpathwaysarecloselyasociatedwiththedevelopment and progresionofCSOM;however，furtherstudiesare neded toexplore the speific mechanismsofactionandinteractionsbetwen these genes and pathways.Thisreview focusesontheimpactofinflammation-related moleculesand theirsignal transduction mechanisms onthe progresionofCSOM，summarizes theresearchadvances inrecentyears，andclarifiestheirexpression，activity，and interactions，so as to provide a reference for subsequent research and clinical treatment.

[Key words] otitis media， suppurative；cytokines； signal transduction； molecular targeted therapy；review

慢性化脓性中耳炎（CSOM）是临床常见耳部疾病，多由细菌感染诱发，典型症状为耳痛、耳道持续分泌物及听力下降，严重影响生活质量。（剩余11559字）