替罗非班联合EVT对急性后循环缺血性脑卒中效果

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[关键词]缺血性卒中;脑梗死;替罗非班;血管内操作;治疗结果;药物相关性副作用和不良反应[中图分类号]R743.3；R972.7 [文献标志码］A [文章编号] 2096-5532（2025）06-0906-05doi：10.11712/jms.2096-5532.2025.61.189 [开放科学（资源服务）标识码（OSID）

[网络出版]https：//link.cnki.net/urlid/37.1517.R.20251231.1016.002； 2026-01-0208：51：20

Efficacy of tirofiban combined with endovascular therapy in acute posterior circulation ischemic stroke ZHANG Qianqian，LIU Ying，MA Fei，HU Xuwei，WANG Di（Department6of Neurology，Xingtai Central Hospital，Xingtai O540oo，China）

[Abstract]ObjectiveTo investigate thetherapeutic eficacyof tirofiban combined with endovascular therapy（EVT）in acute posterior circulation ischemic stroke（APCIS）．MethodsBetween August 2023and December 2024，106 APCIS patients admitted to Xingtai Central Hospital were selected and divided into a control group and an observation group （ n=53 each）using blockrandomization.Patients inthecontrolgroupreceivedEVTalone，whilepatientsintheobservationgroupreceivedtirofibanin additiontoEVT.ThetwogroupswerecomparedforNationalInstitutes of Health StrokeScalescore，90daymodifiedRankin Scale score，succefulrecanalizationrate，acutereoclusionrate，9Odaymortality，symptomaticintracranialhemorrhage incidence， andadversereactionrates.ResultsAfter7and9Odaysoftreatment，theNational Institutesof Health Stroke Scalescores in the observation group were 9.7±3.3 and 5.0±1.0 ，respectively，significantly lower than 12.2±3.8 and 6.9±1.8 in the control group F=68.005 ，118.172；both .After treatment，the rates of favorable prognosis（9O day modified Rankin Scale score ⩽2 ）and successful recanalization rate in the observation group were 66.0% and 88.7% ，respectively，both significantly higher than 45.3% and 67.9% in the control group （ χ2=4.625，6.719 ；both P<0.05 ）.There were no significant differences between thetwogroups inacute reocclusionrate，9Oday mortality，symptomatic intracranial hemorhage incidence，andadversereaction rates （all P>0.05 ）.ConclusionTirofiban combined with EVT can efectively improve neurological deficits and increase the succesful recanalization rate in APCIS patients，demonstrating good prognosis and a favorable safety profile.

[Key words]ischemic stroke；brain infarction；tirofiban；endovascular procedures；treatment outcome；drug-related side effects and adverse reactions

急性后循环缺血性脑卒中（APCIS）是神经科临床中致死致残率最高的卒中类型之一，其病变累及脑干、小脑及丘脑等关键功能区，常导致意识障碍、延髓麻痹及四肢瘫痪等严重症状[1-2]。（剩余10401字）