卵圆孔未闭对隐源性卒中脑血流动力学的影响

打开文本图片集

[关键词]卵圆孔，未闭；缺血性卒中；脑；血流动力学；搏动指数[中图分类号] R541.1；R743.3 ［文献标志码］A [文章编号] 2096-5532（2025）06-0916-05doi：10.11712/jms.2096-5532.2025.61.145 [开放科学（资源服务）标识码（OSID）][网络出版] https：//link.cnki.net/urlid/37.1517.R.20251024.1256.001; 2025-10-2711：29：40

Efects of patent foramen ovale oncerebral hemodynamics in cryptogenic strokeHUANG Tingxing，LI Ling'er，GAO Xiaoli， ZHAO Hongqin，WANGXiaolin（DepartmentofNeurology，TheAfiliated HospitalofQingdaoUniversity，Qingdao266000， China）

[Abstract]ObjectiveToinvestigate therelationship betwenapatent foramenovale（PFO）and cerebral hemodynamics in cryptogenic stroke（CS）．MethodsWeincluded 246patients withCSadmittedtotheNeurology DepartmentofTheAfiliated Hospital of Qingdao University from May 2o16 to December 2023.The patients were divided into CS-PFO0 +） group（121 cases） and CS-PFO （-） group（125 cases）.Based on the presence or absence of a left-to-right shunt （LRS），the patients in the CS-PFO （20号 （+） group were divided intoLRS group（45cases）andNO-LRSgroup（76 cases）.Cerebrovascularrisk factorsand cerebralhemodynamic indicatorswerecomparedacrossdiferentgroups，andtheriskfactors forstrokeinpatientswithPFOwereanalyzed. ResultsThe CS-PFO（+） group showed a significantly higher pulsatility index （PI; t=3.849，P<0.05） and a significantly lower end-diastolic velocity （EDV; t=2.578，P<0.05 ）than the CS-PFO （-） group. PI and EDV differed significantly across the CS（2号 PFO（-） group，LRS group，and NO-LRS group （ F=10.584，4.169 ，both ）. The PI of the LRS group was significantly higher than those of the NO-LRS group and CS-PFO（-）group（both P<0.05） . The EDV of the LRS group was significantly lower than that of the CS-PFO（-）group（ P<0.05） .Anincreased PI was an independent risk factor for stroke in patients with PFO ⟨OR=1.383，P<0.05） .Conclusion Cerebral hemodynamics are impaired in patients with CS complicated by PFO，and LRScausedbyPFOisasociatedwithcerebralhemodynamic impairment.AnincreasedPIisanindependentriskfactorforstroke in patients with PFO.

[Key words]foramen ovale，patent;ischemic stroke；brain；hemodynamics；pulsitility index

病因未明的卒中称为隐源性卒中（CS），约占卒中的 30%～40%∘ 。（剩余8088字）