晚期胃癌病人免疫治疗前后外周血淋巴细胞亚群变化及其临床意义

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[中图分类号] R735.2；R457.2 [文献标志码] doi：10.11712/jms.2096-5532.2025.61.174

[文章编号] 2096-5532（2025）06-0825-06 [开放科学（资源服务）标识码（OSID）]

[网络出版] https：//link.cnki.net/urlid/37.1517.r.20251218.0952.002; 2025-12-19 12：00：24

Dynamicchangesofperipheralbloodlymphocytesubsetsbeforeandafterimmunotherapyinpatientswithadvancedgastriccancerand theirclinical significanceYANGMiaomiao，LIUAina（DepartmentofOncology，TheAfiatedYantaiYuhuangdingHospital ofQingdao University，Yantai 2640oo，China）

[Abstract]ObjectiveToinvestigatethechanges inperipheral bloodlymphocyte subsets inpatients withadvanced gastric cancerbeforeandafterimmunotherapyandtheirclinicalsignificance.MethodsAtotalofI9Opatientswithadvancedgastric cancer whoreceivedatleast fourcyclesof treatment withtheimmune checkpointinhibitor sintilimabin DepartmentofOncology， YantaiYuhuangding Hospital，fromJune222toMay224wereenroled，andaccordingtotreatmentresponse，theyweredivided into progressiongroupwith29patientsand non-progressiongroup with161patients.Thelevelsoflymphocytesubsets beforeand afterimmunotherapywerecomparedbetween thetwo groups，andtheinfluencingfactors forprogresion-freesurvival（PFS）and overallsurvival（OS）wereanalyzed.ResultsAfterfourcyclesof treatment，theprogresiongrouphadsignificantreductions in the levels of CD3+T cells， CD4+T cells，and CD8+T cells （t=2.735-4.703，P<0.05） and a significant increase in the level of NK cells （t=3.969，P<0.05） . There was a significant difference in the baseline value of NK cells between the progression group and the non-progression group （t=2.109，P<0.05） . There were significant differences between the two groups in the changes in （204 CD3+T cells， CD4+T cells， CD8+T cells，and NK cells before and after treatment （t=2.416-5.253，P<0.05） . The number of treatment lines and age were independent influencing factors for PFS（ （P<0.05 ），and the percentages of CD8+7 T cells and NK cells at baseline and the expresson of programmed death-ligand 1 were independent influencing factors for OS （ ⋅P<0.05⋅ .Conclusion Dynamicmonitoringoflymphocytecharacteristicsbeforeandafterimmunotherapyinpatients withgastriccancercanhelptofor mulate individualized treatment regimens and improve the efficacy of immunotherapy.

[Key words]stomach neoplasms；immunotherapy；lymphocyte subsets

胃癌是全球第五大常见恶性肿瘤，也是第三大癌症相关死亡原因[1]。（剩余9110字）