Drg2对IRI介导的心肌细胞焦亡的影响

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中图分类号：R542.2 文献标志码：A

Effect of Drg2 on IRI-mediated Cardiomyocyte Pyroptosis

REN Jia-hao， CHEN Xin-zhe，WANG Tao，WANG Rui-quan，WANG Kun （School of Basic Medicine，Qingdao University，Qingdao 266O7l，China）

Abstract： The regulatory role of GTP-binding protein 2 （Drg2） on I/R-induced cardiomyocyte death was investigated using a primary cardiomyocyte hypoxia/reoxygenation IRI model constructed in suckling mice. In this model， myocardium-specific Drg2 was knocked down and overexpressed to explore the regulatory mechanism of Drg2 in cardiomyocyte death. The results show that knockdown of Drg2 inhibits IRI-mediated cardiomyocyte death，whileoverexpression of Drg2 promotes the elevation of the expression levels of inflammatory factors IL ⋅1β ，IL-18，and lactate dehydrogenase. Drg2 may play a protective role against myocardial IRI by regulating key factors of the cardiomyocyte death pathway.

Keywords： ischemia-reperfusion injury；cardiomyocytes；pyroptosis

心肌梗死是全球范围内死亡的主要原因之一[1-3]。（剩余7461字）