中药调控 NF-κB 信号通路治疗膜性肾病的研究进展

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[关键词]膜性肾病；核因子- ∇⋅κB 信号通路；炎症反应；肾纤维化；免疫反应；足细胞损伤 [中图分类号]R256.5 [文献标志码]A [文章编号]doi：10.3969/j.issn.1674-070X.2025.12.029

Research progress on the regulation of NF- σ⋅κB signaling pathway by Chinese medicines in treating membranous nephropathy

YAN Qiaochu’， DING Xiu， CHEN Yiming'， CHENG Yegangl，2* 1.Hubei UniversityofChinese Medicine，Wuhan，Hubei43Oo6lChina;2.Hubei Provincial Hospitalof Traditional Chinese Medicine， Wuhan， Hubei ， China

[Abstract]Thepathogenesisof membranousnephropathy （MN） iscomplex，involving multiple processsandoutcomes，such asinflammatorysposs，enalrosisdoyteijuryndiuneactios.inemdicinsofedistictivedaagsad thusdemonstratesignificanteficacyintreating MNbyregulatingthenuclearfactor-kB（NF-B）pathway.BasedontheNF-KB signalingpathwaythisstudyelucidatesitspathologicalroleinpromotingtheocurrenceanddevelopmentofMbyanalyzingits involvementinrenalfibrosisinflammatoryresponses，podocyteinjuryandimmunereactions.Furthermore，itsysteticaly summarizesthemechanismsofaction bywhichtheactive ingredients from Chinese medicines，single Chinesemedicines，and compoundfomulasameliorateMNthroughN-KBpathwaymodulation，iming toprovideatheoreticalbasisfortargetingN-kBin the clinical treatment of MN.

[Keywords]membranousnephropathy；nuclearfactor-kBsignalingpathway；inflammatoryresponse;renal fibrosis；immunereaction; podocyte injury

膜性肾病（membranousnephropathy，MN）又称膜性肾小球肾炎，是一种以肾小球损伤为突出表现的组织学模式I，其特异性病变是肾小球毛细血管壁明显增厚，基底膜外侧形成免疫复合物的结果2。（剩余14182字）