口腔及肠道微生物与儿童全身系统性疾病的相关性研究进展

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[中图分类号]R725.9 [文献标志码] A[doi] 10.7518/gjkq.2025097

[Abstract]Theoralcavityisagatewaytothegastrointestinaltract.Therelativeabundanceofcommonoralbacteriain theintestineofindividualswith systemic diseases increases.Theoral microbiota interact with the intestinal microbiota， which induces intestinal dysbiosisand intestinal mucosadamage.Compared with theoraland intestinal microbiotaof adults，those of childrenare more sensitive to external stimuli，and theychange dynamically with growth and development.Childhoodmaybethecriticaltimeformicrobiota interventionstopreventdiseases.Thisreviewdiscussestheestablishmentanddevelopmentoforalandintestinalmicrobiota.Therelationshipbetweenoralmicrobiotaandintestinalmicro biotainchildrenwithsystemicdiseases isalsodetermined.Thisreviewofersnewavenues fortheprevention，diagnosis， and treatment of diseases.

[Key words] oral microbiomes; gastrointestinal microbiomes;children; system diseases

微生物群落通过与宿主相互作用，影响宿主的生理代谢功能和免疫系统稳态[1-2]。（剩余20510字）