复方丹参滴丸治疗口腔扁平苔藓的潜在靶标

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[中图分类号]R78[文献标志码]A[doi] 10.7518/gjkq.2025063

[Abstract]ObjectiveThis study aimed to forecast the potential targets of compound Danshen dripping pill（CDDP） in treating oral lichen planus OLP（OLP）via network pharmacology and molecular docking.MethodsThe active compounds and targets ofCDDP were searched in the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform.Thedisease targetsofOLPwereobtained from multipledatabases，suchasDisGeNET.Adrug-compound-target network wasconstructed byintersectingthe targets to screen the keyactive components.Aprotein-protein interaction network wasalsobuiltby intersecting the targets toselect the keyones.Target intersection was alsoapplied

forgene ontology（GO） and Kyoto Encyclopediaof Genesand Genomes （KEGG） enrichment analyses.The molecular docking and visualization ofkeyactive componentsand targetswere also performed.Results A total of 469 drug-disease intersecting targets were found. The key active components were bornyl acetate，dan

shexinkum D，anddanshenolA，andthekeytargets were proteinkinaseB（AKT1），E1Abinding protein p30（EP300）， and estrogen receptor1（ESR1）.GOenrichment analysis indicated that the resultsof intersection targets included protein serine/threoninekinaseactivityinflammatoryresponse，signalransduction.KEGGenrichmentanalysisrevealedvarious pathways such as cancerandAGE-RAGE signaling pathway in diabetic complications.Moleculardocking showed that the results of AKT1，Harvey rat sarcoma virus （HRAS），and the three key active components were all ⩽- 5.0kcal/mol ConclusionInOLP treatment，theactivecomponents ofCDDP mayparticipate in immunefunction，reduce oxidative stres，inhibit inflammationbyacting onmultipletargets suchasAKTlandHRAS，andregulatepathways including cancer and AGE-RAGE signaling pathway.

[Key words]oral lichen planus;compound Danshen dripping pil;network pharmacology;drug target；molecular docking

口腔扁平苔藓（orallichenplanus，OLP）是最常见的口腔黏膜慢性炎性疾病之一，患病率约0.1%～4.0% ，主要表现为口腔黏膜粗糙、疼痛不适，可影响正常进食、语言和吞咽等，导致生活质量下降。（剩余15273字）