神经肽参与调控神经病理性疼痛机制的研究进展

打开文本图片集

[Abstract]Thepathological mechanismsoforofacial neuropathic painarecomplex.Currntly，the lackoflong-lasting andefectiveclinical treatmentdrugsgreatlyburdens thelivesofpatients.Neuropeptides，includinggalanin，calcitonin gene-related peptide，neuropeptideY，ndoxytocin，amongothers，canegulate nociceptivetransmissionthroughieent signalingpathways，thus playingacrucialrole inthepathological processesofneuropathicpain.At present，theroleand mechanismofneuropeptides inorofacialneuropathicpainareelativelyinsuicient，andthereisalackofsuficientclinicalevidenceregarding neuropeptides as therapeutic targets fororofacialneuropathicpain.Thisarticle summarizes mechanisms ofneuropeptidesin theperipheral andcentral nervous systems to provide new ideas for exploring their role and mechanisms inorofacial neuropathic pain，and to recommend effective strategies fordeveloping newanalgesic drugs.

[Key words]neuropeptides；orofacial neuropathic pain；central nervous system；peripheral nervous system；signaling pathways

根据国际疼痛研究协会（InternationalAssocia-tionfortheStudyofPain，IASP）的定义，疼痛是一种与实际或潜在组织损伤或与这类损伤描述相关的不愉快的感觉和情感经历[]。（剩余22349字）