黄芪活性成分调控NLRP3炎症小体延缓糖尿病肾病机制

[Abstract]Diabeticnephropathy（DN）isoneof the most prevalent microvascular complications ofdiabetes melitus （DM）， characterizedbyprogesivenaldfuntionultiatelyeadingtondstagerenaldisease.Th“inflmmatorysponse-fbos”ais playsacicaloleinteprogessonof，withteNOD-likeeceptorthalproteinomai-assiatedprotein3la masomerecogedasakydivroftisprocess.Understandingteinterplaybetweeniflmationrosis，ndNflsomeactivatioisessntialfordevelopingefectivestrategiesforDpreventionandtreatmentAtragalusmembranaceusisawidely usedtraditioalChinesemedicineinDNmanagement，anditsactivecomponentshavebenshowntointerferewithNRP3inflammsomeinititonandactivatonterebymitigatingDprogresion.TiseviewhglightsthepivotaloleofteNRP3inflmsoein the“inflammatoryresponse-fibrosis”mechanismofNandexploresthetherapeuticpotentialofAstragalus membranaceusinargeting NLRP3inflammasomeactivityBysummarizingcurentevidence，thisarticleaims toprovidenewinsightsintotargetedtherapetic strategies for DN.

[KeyWords]Astragalus memeranaceus；Activecomponent；NOD-likereceptorthermal proteindomainassciated protein3; Diabetic nephropathy；Renal interstitial fibrosis；Inflammatory

糖尿病肾病（Diabeticnephropathy，DN）是糖尿病最主要的微血管并发症之一，以肾小球硬化、肾间质纤维化（Renalinterstitial fibrosis，RIF）为结局，走向终末期肾病。（剩余11648字）