氨溴索与头孢哌酮钠舒巴坦钠联合治疗 老年重症肺炎的临床疗效

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[Abstract]ObjectiveToinvestigatetheclinicalefcacyof ambroxolcombined withcefoperazonesodiumandsulbactam sodiumithetreatmentof elderlypatientswithseverepneumonia.MethodsAtotalof1elderlypatients withseverepneumoiaadmited to our hospital from January 2O22 to December 2O23 were selected and divided into study group （ n=50 ，treated with ambroxol combined with cefoperazone sodium sulbactam sodium）and control group（ n=50 ，treated with cefoperazone sodium sulbactam sodium）accordingtoandomumbertable.After2weeksoftreatmentthetetodisappearanceofclinicalsymptoms，pulmonaryfunction （forcedexpiratoryumeincond，forcedvitalcaacitymaiummd-expiratoryflopeakepiratoryflowrate），ocadialin jurymarkers（N-terminal pro-brain natriuretic peptide，creatine kinase-MB isoenzyme， α -hydroxybutyratedehydrogenase），inflammatoryfactorsandimuneprameters（reactieproten，rocalcitoinD4ligandascularcelladesionmoleule-1），ceiologyandchronichealthstatusscoreswerecomparedbetweenthetwgroups.ResultsAftertreatment，thedisappearance timeof clinical symptoms in study group was significantly shorter than that in control group （ P<0.05 ）；the lung function indicators increased， thelevelsofyocadialijuyarkesdecreased，theiflammatorfctorsdimuneinicatorsereasedndthcuteiology and chronic health status scores decreased in both groups，and the study group was superior to the control group（ P<0.05 ）. ConclusionAmbroxolcombinedwithcefoperazone sodiumandsulbactamsodium inthetreatmentofelderlypatients withseverepneumonia， comparedwithcefoperazone sodiumand sulbactamsodiumalone，can efectivelyshortenthetimetodisappearanceofclinical symptoms，mprovelungfunctionandreducemyocardialinjurymarkersandinflammatoryfactorlevels，therebypromotingrapidrecoveryof patients.

[Key words] Severe pneumonia；Ambroxol；Cefoperazone sodium and sulbactam sodium；Lung function；Clinical efficacy

重症肺炎（Severepneumonia，SP）因高发病率、高死亡率和诊治难度成为临床关注的重点[1]。（剩余11024字）