血清活性氧水平对老年慢性肾脏病患者进展 为终末期肾病的预测价值

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[Abstract]ObjectiveTo analyze the predictivevalue of serum reactive oxygen species（ROS）levels in end-stage renal diseaseourrenceamong elderlypatientswithchonickidneydisease.MethodsAtotalof174chronic kidneydiseasepatintswho receivedtreatmentattheFirstAfliatedHospitalofXinjangMedicalUniversityfromJanuary22OtoDecember2O23wereselectedas theresearchsujects.Patientsweredividedintoaprogressivegroupandanonprogressvegroupasedonwetherteyhadprogesed to end-stagerenaldisease，with49casesinteprogresivegroupand25casesintennprogressivegroup.Baselinedateswerecollectedusingacommercalednz-linkedimunosobentssykittodetectsermROSlevelsinpatientsMultivaratelgisticre gressionmodelswereusedtoanalyzethecorelationbetweenserumROSlevelsandchronic kidneydiseaseprogresson，andROC curves wereusedtoanalyethepredictivefcacyofserumROSlevelsfortheprogresionofchronickidneydisease toend-stageenal disease.ResultsAge，maleproportion，systolicblood presure，and24-hoururinary proteinquantificationandsumerROSlevels in the progressive group were higher than those in the non progressive group （ P<0.05 ），while estimated glomerular filtration rate was lower than that in the non progressive group （ P<0.05 ）. Multivariate logistic regression lines showed that serum ROS was an independentriskfactorforprogressontoend-stagerealdiseaseinelderlypatietsithhroncidneydseaseafeadjustingforofouders （ P<0.05 ）.ROC curves showed that serum ROS cut-off value for predicting progresson of chronic kidney disease was 14.61ng/mL ，predicted AUC was 0.81（ 95% CI： 0.75 to 0.88），sensitivity was 84.8% ，and specificity was 70.2% . Conclusion SerumROSlevelsaresignificantlyasociatedwithteiskofprogesiontend-stagenaldseaseielderlypatientswithconckidney disease and have some predictive value.

[Key words] Chronic kidney disease；Serum reactive oxygen species；End-stage renal disease；Predictive value

慢性肾脏病是一种长期慢性化的疾病，其特征是随着时间的推移肾功能丧失，导致肾衰竭和终末期肾病，即慢性肾脏病的最后阶段[1]。（剩余6224字）