药物基因检测在颅内药物涂层球囊术后的作用

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[Abstract]ObjectiveToobservethediferencebetweenantiplatelettherapyafterdrug-coatedballonangioplasty guided bydrug genedetectionandconventionalantiplatelettherapy，andevaluatethebenefitdruggene guidedmedication.Methods80 elderlypatientshounderwentdugcoatedballonangioplastyforintracranialarterystenosisfromJune222May23intheDepartmentNeurologyIthePeople’sJinanwereseletedasthestudysubjects.Aordingterandomubertablemethod，thepatientsweredividedinadruggenedetectiongroup（groupA）andanon-druggenedetectiongroup（groupB）， with40cases ineachgroup.Afterhalfayearand1year reatment，digitalsubtractionangiography，brainmagneticresonanceangiographyandbraincomputedmographyangiographywereusedessthevasularstausandcompare theoccurenceendpointevents.ResultsSix monthsafteroperation，there wasnosignificantdiference incoagulationindexes betweenthetwogroups（ P> 0.05）.There wasno significant difference in epistaxis，gingivalbleeding andurinarybleeding between thetwo groups （ P>0.05 ）； the gastrointestinal bleeding rate in group A was lower than that in group B（ P<0.05 ）；the tal number haemorrhagic events in group A was lower than those in group B （ P<0.05 ）.After 1-year follow-up，the overall endpoint events in group A were lower than those in group B ，and the difference had a statistical significance （ P<0.05 ）.ConclusionAfter drug-coated balloon angioplasty， theselectionantiplateletdrugsafterdruggenedetectioncanreducetheshort-teriskbleeding，improvethelong-temprogosis and delay the occurrence endpoint events in elderly patients.

[Keywords] Drug gene detection；Drug-coated balloon；Angioplasty；Dual antiplatelet therapy

颅内动脉粥样硬化性狭窄（Intracranialathero-scleroticstenosis，ICAS）是缺血性脑卒中发病最主要的病因，占全部病因的 30%～50%[1] 。（剩余9921字）