动物源宿主防御肽抗微生物作用机制研究进展

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中图分类号：S852.42 文献标志码：A 文章编号：0366-6964（2025）09-4294-09

Research Progress on the Mechanism of Host Defense Peptides against Microorganisms

PAN Yandi，ZHANG Tingting，FANG Rendong，PENG Lianci* （College of Veterinary Medicine， Southwest University， Chongqing 400715， China）

Abstract： Host defense peptides （HDPs），as antimicrobial peptides （AMPs），are an important component of innate immunity and can protect the host against pathogens invasion. HDPs have broad-spectrum antimicrobial activity and are less susceptible to the production to drug resistance，which are potential candidates for the development of new anti-infectives. The antibacterial mechanism of action of HDPs is complicated，which not only acts on cell wall and membrane，but also affects the synthesis of nucleic acid，protein and metabolism. This article reviews the mechanism of action of HDPs on pathogens including bacteria，fungi， viruses，and parasites，which provides reference for the application of HDPs.

Keywords：host defense peptides；microorganisms；the mechanism of action ∗ Corresponding author：PENG Lianci，E-mail： penglianci@swu.edu.cn

近年来由于抗生素的滥用，细菌耐药性已经发展成为威胁全球公共卫生安全的问题，因此迫切需要开发抗生素的替代品。（剩余21054字）