畜禽 m6A 甲基化修饰及营养调控研究进展
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中图分类号：S852.2 文献标志码：A 文章编号：0366-6964（2025）09-4215-17
Advances in m6A Methylation Modification and Nutritional Regulation in Livestock and Poultry
BAI Guangdong，LOU Zekai， WANG Ruiqi， ZHAO Xuan， LI Jiawei， XIA Yaoyao， PANG Jiaman*（College of Animal Science and Technology， Southwest University， Chongqing 4Oo715，China
Abstract：N6-methyladenosine （ m6A ）methylation represents a dynamic and reversible posttranscriptional modification regulated by m6A methyltransferases， m6A demethylases，and m6A reader proteins. It is recognized as the most prevalent RNA modification in eukaryotic organisms. Recent studies have progressively elucidated the biological roles of m6A methylation in livestock and poultry production， highlighting its involvement in regulating critical life processes， including growth and development， reproductive physiology， glucose and lipid metabolism，oxidative stress，and cellular damage. Alterations in factors such as nutrition， environment，and disease within livestock and poultry production can disrupt m6A methylation modifications， thereby impacting the physiological metabolic processes of these animals. Nonetheless， nutritional regulation strategies have the potential to restore methylation homeostasis，thereby facilitating the regulation of growth，development， and diseases in livestock and poultry. This article provides a comprehensive review of these topics，offering novel insights and strategies for enhancing growth performance and ensuring the health of livestock and poultry.
Keywords ： m6A methylation modification; methylation homeostasis； nutrients regulation; livestock and poultry
∗ Correspondingauthor：PANG Jiaman，E-mail：pangjm swu. edu. cn
N6-甲基腺苷（N6-methyladenosine， m6AΩ 甲基化修饰即指在 m6A 甲基转移酶（methyltransferase）的催化下将甲基基团 （-CH3 ）转移至RNA腺嘌呤核苷酸的N6位取代氢（-H）的转录后修饰方式，是哺乳动物中普遍存在的一种动态、可逆的表观遗传修饰，约占RNA 甲基化修饰的 80%[1] 。（剩余42381字）
