动物的性别决定基因及其甲基化调控的研究进展

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中图分类号：S183.2 文献标志码：A 文章编号：0366-6964（2025）09-4129-14

Research Progress on Sex Determining Genes and Their Methylation Regulation in Animals

LIN Xiao，LI Ruijie，LIU Long，GENG Tuoyu*，GONG Daoqing* （College of Animal Science and Technology， Yangzhou University， Yangzhou ， China）

Abstract： Sex determination in the sexually reproducing animals refers to the phenomenon in which the animals develop into female or male individuals and exhibit morphological and physiological differences after gender differentiation. Sex determination in animals is divided into environmental and genetic types. Currently，it has been identified that some genes play important roles in animal sex determination. The sex determination of animals is also closely related to DNA methylation， such as the global DNA methylation of mammalian X chromosome. However，the role of DNA methylation in sex determination varies significantly among different animal species. This article reviews the influencing factors and key genes of animal sex determination，as well as the association between DNA methylation of genes and sex determination in different species，which provides useful references for further research on the mechanism of animal sex determination.

Keywords： DNA methylation； sex determination； animal; differentially expressed genes; epigenetic regulation

∗ Corresponding authors： GENG Tuoyu， E-mail：tygeng@ yzu. edu. cn; GONG Daoqing，E-mail： yzgong@163.com

1动物的性别决定

1.1 研究动物性别决定的意义

多细胞动物存在有性繁殖，个体分为雌性和雄性。（剩余27680字）