热应激通过干扰生物钟系统影响反刍动物消化道屏障功能的研究进展

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中图分类号：S815.4 文献标志码：A 文章编号：0366-6964（2025）09-4204-11

ResearchProgress of Heat Stress Affect Digestive Tract Barrier Function of Ruminants by Interfering with Biological Clock

YI Huanming1'²，BAO Guosheng1'²，WAN Hui1'²，OU Jingyu 1，2 ，HE Xiaolong 1，2 REN Chunhuan 1，2 ，CHEN Jiahong^， ZHANG Zijun1，²，WANG Qiangjun 1，2 * （1. College of Animal Science and Technology， Anhui Agricultural University， Hefei 230036， China ; 2. Anhui Provincial Key Laboratory of Conseruation and Germ plasm Innooation of Local Livestock and Poultry Genetic Resource，Hefei 230o36，China ; 3. Jianghuai Watershed Comprehensive Experiment Station of Anhui Agricultural University， Dingyuan 233282， China）

Abstract： In recent years，as the global greenhouse effect has become more serious， frequent extreme weather has caused huge economic losses to animal husbandry. Especially in the summer when heat waves are frequent， continuous high temperatures can cause heat stress reactions in ruminants，resulting in stunted growth and development， increased mortality，and serious restrictions on the high-quality development of animal husbandry. Studies have found that heat stress has a particularly significant impact on the intestinal health of young ruminants，causing disordered intestinal microbial flora structure，oxidative stress damage，and increased barrier permeability. However，most existing studies only explore intestinal damage caused by heat stress at a single time point，but the latest research reveals that intestinal barrier function is not static but shows circadian rhythmic changes. To this end，this article reviews the effects of heat stress on the circadian rhythm of the digestive tract biological clock and barrier function of ruminants on a diurnal time scale，in order to find potential pathways and mechanisms for heat stress to regulate digestive tract barrier function through the biological clock，and provide new ideas for precise production and environmental management of ruminants.

Keywords：heat stress；biological clock；digestive tract barrier ∗ Corresponding author： WANG Qiangjun，E-mail： wangqiangjun@ahau. edu. cn

自1980年以来，全球气温每十年上升 0.18∘C ，是1880年以来增速的两倍。（剩余24859字）