乌司他丁联合抗生素治疗对老年重症肺炎患者呼吸道纤毛清除功能的影响

打开文本图片集

关键词：乌司他丁；抗生素；老年；重症肺炎

中图分类号：R563.1文献标志码：A 文章编号：2097-7174（2025）10-0961-05

DOI：10.3969/j.issn.2097-7174. 2025.10.007

Abstract：Objective：Toinvestigate theeffectofulinastatincombined withantibiotics onrespiratoryciliaclearance function in elderlypatients with severepneumonia.Methods：Atotalof1O2elderlypatients withsevere pneumonia who were treated in Kaifeng People's Hospital from January 2O24 to January 2025 were included.According totherandom numbertable method，the102 patients were divided intothecontrol groupand theobservationgroup，with51patients in eachgroup.Thecontrolgroup wastreated withantibiotics，whiletheobservationgroupwastreated withulinastatincombined withantibiotics.Thetreatmentcoursesforbothgroups were14days.Theeficacyofthe twogroupswascompared， including thedifferences inrespiratory tractciliaclearancefunctionMucociliaryclearancerate （MCCR），Sputumviscosity， Ciliaswing frequency（CBF）]，inflammatory factors[Interleukin-6（IL-6），Tumor necrosis factor- α （TNF- ），C-reactive protein（CRP）]before and14 days after treatment.Results： The total efectiverate in the observation group was higher than that in the control group（ P<0.05 ）.After14 days of treatment，MCCR and CBF in the observation group were higher than those in the control group（ P<0.05 ），while sputum viscosity was lower than that in the control group （ P<0.05 ）.Atthe same time，serum IL-6，TNF- αα∝α and CRP levels in the observation group were lower than those in the control group （ P<0.05 ）.Conclusion：Ulinastatin combined with antibiotics can effectively improve the cilia clearance functionoftherespiratory tractin elderlypatientswith severepneumonia，reduce inflammatoryresponse，and improve clinical efficacy.

Keywords：Ulinastatin；Antibiotics；Elderly；Severe pneumonia

重症肺炎是老年人群中常见危急病症，其病死率一直维持在较高水平[1]。（剩余5225字）