多西环素治疗8岁以下儿童耐药肺炎支原体肺炎可行性分析

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中图分类号：R725 文献标志码：A 文章编号：2097-7174（2025）10-0957-04

DOI：10.3969/j.issn.2097-7174.2025.10.006

Abstract： Objective：Toexploretheclinicaleficacyandsafetyofdoxycyclineinthetreatmentofdrug-resistantmycoplasma pneumoniae pneumonia （MPP）in children under8 years old，and to analyze the safety of doxycycline used in young children.Methods：Thisstudyincludedchildrenwith drug-resistant MPPwhowerehospitalizedinthepediatrics departmentofTheFirstPeople's HospitalofNankangfromJanuary2024toApril2O25（116cases），and their clinical data was colected.The patients were divided into control group（6Ocases）and study group（56cases）.Thecontrol group were treated with azithromycin + methylprednisolone，while the study group were treated with doxycycline + methylprednisolone. Compare the therapeutic efects andadversereactions ofthetwo groupsof children.Results：After clinical intervention， thefeverremision time，the timeof improvement of pulmonarysigns，and the length of hospital stayin thestudy group were shorter than those in the control group，with statistical significance（ P<0.05 ）. The treatment response of children in the study group was significantly beter than that in the control group，with statistical significance（ P<0.05 ）. There was no statistically significant diference in adverse reactions between the two groups（ P =0.909）.Conclusion：The clinicalefficacyofdoxycyclinecombinedwithmethylprednisooneinthetreatmentofdrug-resistantMPPinchildrenunder 8yearsoldissignificantlybetterthanthatofazithromycin.Itcansignificantlyshortenthetimetofeverresolution，the timetoreliefofpulmonarysigns，andthelengthofhospitalstayinchildren，andthe incidenceofadversereactionsoforal doxycycline treatment is low.

KeyWords：Doxycycline；Azithromycin；Methylprednisolone；Mycoplasma pneumoniae pneumonia，drug resistance; Children

肺炎支原体肺炎（Mycoplasmapneumoniaepneumonia，MPP）是我国儿童社区获得性肺炎的常见类型。（剩余4867字）