蛋白琥珀酰化修饰：代谢重编程中的调控方式

打开文本图片集

中图分类号：Q26 文献标志码：A 文章编号：1001-5779（2025）06-0580-06

DOI：10.3969/j. issn. 1001-5779.2025.06.012

Succinylation-mediated metabolicreprogramming ： unveiling novel regulatory mechanisms

HUANG Ben-ben’，LIU Jing'，ZHAO Li-wen’，ZHONG Jia-ning1，² （1.SchoolofBasicMedicine，GannanMedical University；2.KeyLaboratoryofMinistryof EducationforPreventionand Treatment of Cardiovascular and CerebrovascularDiseases，Gannan Medical University，Ganzhou，Jiangxi ）

Abstract：Protein succinylationmodificationisan emerging post-translational modification（PTM）method.Itregulates keybiological metabolic pathways byaltering theactivityor stabilityof metabolic enzymes andthereaction process of substrates.This PTMiswidely involvedintheregulationof biochemical metabolic processessuchas energy metabolism， carbohydrate metabolism，lipid metabolism，andaminoacid metabolism，and afects celllar processs such as cel proliferationandapoptosis.Therefore，proteinsuccinylationmodificationisnotonlyanimportantbridgeconnectingcellular metabolismandcellularfunctions，butalsooneof theimportant factors influencing metabolicregulationandtheoccurrence anddevelopmentof diseases.Thelatestresearchshowsthatproteinsuccinylationmodification iscloselyrelatedtothe occurrenceanddevelopmentofsome metabolicdiseasessuch as diabetes andcancer.This articlereviewsthelatestresearch progress of protein succinylation modification in cellular metabolic processes and related diseases.

KeyWords：Post-translational modification;Protein succinylation；Cellular metabolism

蛋白质翻译后修饰（Post-translationalmodifica-tion，PTM）是指蛋白质在一个或多个氨基酸位点的共价翻译后修饰，是蛋白质生物功能的重要调节方式。（剩余15823字）