老年人群高尿酸血症及痛风发病影响因素研究进展

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关键词：高尿酸血症；痛风；老年人；影响因素

中图分类号：R589.7文献标志码：A 文章编号:1001-5779(2025)06-0519-05

DOI:10.3969/j.issn.1001-5779.2025.06.001

Research advances in the influencing factors of hyperuricemia and gout in the elderlypopulation

LI Jing (Guangnei Community Health Service Center,Xicheng District，Beijing City,Beijing 100053)

Abstract :With theaccelerating pace of population aging，the prevalence of hyperuricemia（HUA）and gout in elderly populations has risensignificantly，emergingasacritical publichealthconcern.Thisarticleprovidesasystematicreview of the multipleinfluencingfactorsandtheirinteractive mechanisms inthepathogenesisofHUAandgoutamong theelderly. Thedevelopment of HUAandgout intheelderlypopulations isclosely linked togeneticpredisposition，metabolic abnormalities（suchasinsulinresistanceanddyslipidemia），lifestyle（high-purinediet，alcoholintake，physical inactivity），comorbid conditions（hypertension，chronic kidneydisease，obesity），and medication use（diuretics， immunosuppressnts).Among these，age-related renaldysfunctionandreduceduricacid excretion capacityconstitute thecorepathophysiologicalbasisforthehighprevalenceofHUAinolderindividuals.Recentstudies highlightthatthe interaction between environmental factors（seasonal variations，airpolution）and genetic factors（polymorphisms in ABCG2and SLC2A9genes）furtheramplifiesdiseaserisk intheelderly.Consideringtheuniquecharacteristicsof elderly patients，astratifiedmanagementstrategisdvocated,integratingthepinciplesofprecisionmedicinetooptimizelstyle modifications,pharmacotherapyselection,andcomorbiditymanagement.Futureresearchshoulddelveintoaging-assocated molecular mechanisms，novel biomarkers，and targeted therapeutic strategies toprovidereferences for personalized prevention and treatment of HUA and gout in elderly population.

Keywords:Hyperuricemia;Gout；Elderlypeople；Influencingfactors

高尿酸血症(Hyperuricemia，HUA)是备受关注的嘌呤代谢异常疾病[1。（剩余10976字）