黑色素瘤缺乏因子2样受体在机体抗细菌和真菌感染中的作用

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关键词：黑色素瘤缺乏因子2样受体；细菌感染；真菌感染；炎症小体；免疫调节 中图分类号：R392.11文献标志码：A文章编号：1001-5779（2025）06-0570-10 DOI：10.3969/j.issn.1001-5779.2025.06.011

Research progress on the role of AIM2 like receptors inhost defense against bacterial and fungal infections

ZHENG Si-ping'， JIANG Qian²，LIU Zhi-ping³ （1.The First Clinical Medical SchoolofGannan Medical University；2.Schoolof Nursing，Gannan Medical University; 3.School of Basic Medicine，Gannan Medical University，Ganzhou，Jiangxi341000）

Abstract：The innate immune response serves as theprimary defense against pathogenic infections，with AIM2-like receptors（ALRs）representing pivotal components of the intracelular DNA-sensing receptor family.These receptors detect pathogen-derivedor host-derivedDNA，therebycontributing to intrinsicimmune defense mechanisms.Although theroleofALRsinantiviralimmunityhasben wellcharacterized，theirregulatorynetworksandfunctional heterogeneity inbacterialandfungalinfectionsremaininsuffcientlysummaized.Thisreviewintegatesrecentadvances tosystematically elucidatethe mechanisms ofAIM2and itsfamilymembersagainst bacterialand fungal pathogens.Speci ficall，AIM2 exertsanti-infective efects byinflammasome assmbly（recruiting ASCandactivating Caspase-1through pro-Caspase-1 binding），leading to pyroptosis and proinflammatorycytokine release，whereas other members like IFI16mediate broadspectrumantimicrobialactivityvia inflammasome-independentpathways，suchasdirectpathogen DNA binding to inhibit replication orcGAS-STING-mediated typeIinterferonresponses.These findingsdemonstrate that ALRscoordinately regulateanti-infectionimmunitythroughmultimodalmechanisms，andtheirpathogen-specificDNArecognitionpattrns offer novel perspectives for targeted therapeutic interventions against infectious diseases.

KeyWords：Absentinmelanoma2-likereceptors；Bacterialinfection;Fungalinfection;Inflammasome;Immunegulation

先天性免疫是人体抵御外来人侵者的第一道防线。（剩余20442字）