茉莉花、柚子叶、橘叶提取物对模型反应中PhIP的抑制效果研究

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中图分类号：S666 文献标志码：A 文章编号：1671-4652（2025）02-0090-08

ABSTRACT：Theaimof this study was to investigate theinhibitory effectof jasmineflower，pomelo leaf and orange leaf on 2-amino-1-methyl-6-phenylimidazo[4，5-b]pyridine（PhIP）generated ina chemical model system.The flavonoid extracts of jasmine flower，pomelo leaf andorange leaf with diferentadditive amounts wereadded intoa chemical model system with phenylalanine and creatinine as precursors forthe reaction，and UPLC-MS was used to monitor the changes of thecontentsofprecursors，intermediate phenylglycolaldehydeandtheproduct PhIPinthemodelreaction toexplore the inhibitoryefects.Theresults showed thatthe threeextracts exerted significant inhibitory effects on the generationof PhIP，with 59‰ when orange leaf extract was added at 0.06g ， 56.98% when grapefruit leaf extract was added at 0.06g ，and 53.13% when jasmine flower extract was added at 0.08g . It was concluded that jasmine flower，pomelo leaf andorange leaf flavonoid extracts significantly inhibited heterocyclicamine PhIPin the folowing order：orange leaf extract>pomelo leaf extract>jasmine flower extract.

KEY WORDS： plant extracts； chemical model response system;PhIP； inhibitory effect杂环胺（heterocyclic aromatic amines，HAAs）是肉类食品在高温烹调过程中热解形成的低分子有机胺化合物，是食品热加工过程中产生的具有致突变性和致癌性的一类化合物[1l。（剩余14479字）