白藜芦醇提高试验小鼠卵子质量及胚胎发育率的促生产效应
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中图分类号：S865.1；R285.5 文献标志码：A 文章编号：1671-4652（2025）02-0025-07
Promoting effect of resveratrol on egg quality and embryo development rate of experimental mice
LI Xiuxiu 1，2 ，LI Xiaoya³，TIAN Zhenhao4，LIU Xiangyu²，YANG Haiming ∘ ，CUI Yuehua （1. College of Biological Science and Technology， Yangzhou University， Yangzhou 225oo9，China; 2. Changzhou Cavens Model Animal Company Limited， Changzhou 2l3loo，China; 3. Key Laboratory of Molecular Microbiology and Technology， Ministry of Education， Nankai University，Tianjin 300457，China; 4. School of Life Sciences， Northwestern Polytechnical University，Xi'an 71o129，China; 5. College of Animal Science and Technology， Yangzhou University， Yangzhou 225009，China）
ABSTRACT：To investigate the effects of resveratrol （RSV）on ovulation volume，fertilized egg development，and litter yield of mice，18 aged 3-4 weeks C57BL/6J female mice were intraperitoneally injected with pregnant horse serum hormone （PMSG，10 U per mouse）for hyperexcretion as a blank control group，18 micein the experimental group were simultaneouslyintraperitoneally injected withRSVand18miceinthe negativecontrol group were simultaneouslyinjected with dimethyl sulfoxide （the volume fraction was 1% DMSO）. The number of ovulated eggs，in vitro fertilization ability of eggs，developmentalabilityoffertlizedeggs inrecipientmice，and posttransplant literrateineach groupof mice were observed and analyzed.The results showed that the average number of ovulations and cleavage rate in vitro，blastocyst formation rate，implantationrateandliterrateoffertilized eggs intheuterus of recipient mice with ICR（without RSV injection） in the experimental group were （ （34.02±5.54） ， （90，37±1.84）% ， （93.89±3.47）% ， （68.89±4.19）% ，and （ （51.94±3.76）% ，respectively，which were significantly higher than those in the blank group and negative control group （ ⋅P<0.05） . To sum up，intraperitoneal injection of RSV can significantly improve the reproduction performance and fficiency of experimental mice during superovulation.
KEY WORDS：mice；resveratrol;embryonic development；litter rate
试验小鼠是人类疾病的动物模型，可用于新药的研发和测试、疾病的预防与治疗等生物医学研究。（剩余11573字）
