颗粒蛋白前体在慢性气道炎症性疾病中的研究进展

[Abstract]Progranulin，asecreted glycoprotein，ispivotalinthedevelopmentandadvancementofchronicairwayinflammtorydiseases，enderingitapromisingoveldiagnosticbiomarkerandpossibletherapeutictarget.Thiseviewencapsulatescuentpro gressincompreendingterbutes，gicalledpotetialplicatiosfpralininagosisndtreatof nicairwayinflammatorydiseasesTerultsseektooferovelisightsfoearlyagosis，iseasesurveillnce，andiloteat ment approachesinairwayinflammatorydisorders，includingchronicobstructive pulmonarydisease（COPD）andasthma.Thisreview aimstoexpeditetetraslationofprogaulielatedfiingfrofudametalseachtolincalacationstablisngaoeicalbasisforenancingpatientoutcomesand investigating innovativediagnosticandtreatmentstrategies inrespiratorymedicie.

[Key words] Progranulin；Chronic airway inflammatory diseases；Chronic obstructive pulmonary disease；Asthma

慢性气道炎症性疾病是指炎症累及上和（或）下气道的慢性疾病，以气道炎症、气道阻塞及气道重塑为主要特征，以慢性阻塞性肺疾病（Chronicobstructivepulmonarydisease，COPD）及支气管哮喘（Bronchialasthma，BA）为代表。（剩余13145字）