MRI评估细胞外容积分数对老年鼻咽癌患者淋巴结转移的预测价值

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[Abstract]ObjectiveTo investigate the predictive valueof MRI forevaluating extracelllar volume fraction（ECV）for lymphnodemetastasisinelderlynasopharyngealcarcinomapatients.MethodsAtotalof11elderlynasopharyngealcarcinomapatientsadmitedtoNo.9O4JointLogistcalSupportForceHospitalofLAandtheFirstAilitedHospitalofNavalMilitaryMedicalUniversityfromJulytoFebruaryO24wereereretrospectivelyanalzedAcordingtotheresultsofpostoperativepathologicalexaminatio，thepatientsweredividedintoalymphnodemetastasisgroup（36cases）andanolymphnodemetastasisgroup（85cases）AllpatientsunderwentMRIandECVwascalculated.Multivariatelogsicregressonmodelwasusedtoanalyetheinfluencing factorsof lymph node metastasis.ROCcurve wasused toanalyzethe predictive valueofECVforlymph node metastasis.ResultsThe TNM stage II proportion，low differentiation proportionand ECV level in lymph node metastasis group were higherthan those in no lymph node metastasis group （ P<0.05 ）.Multivariate logistic regressionanalysis showed TNM stage ，lowdifferentiation，high ECV were influential factors for lymph node metastasis （ P<0.05 ）.ROC curve analysis showed that ECV had a high predictive efficacy for lymph node metastasis，with an AUC of 0.877（ 95% CI：0.806 to 0.948， P<0.001 ），acut-off value of 21.21% ，a sensitivity of 0.722，aspecificityofO.953，andaYouden indexof0.675.ConclusionECVassessd byMRIisofgreatvalueinpredicting lymph nodemetastasisinelderlynasopharyngealcarcinomapatients，andECVcanbeusedasanefectiveclinicalreferencedex.

Key Words]Nasopharyngeal carcinoma；Extracellular volume fraction；Lymph node metastasis

鼻咽癌是一种起源于鼻咽部的上皮肿瘤，老年患者由于生理特点及多病共存的情况，常面临更为复杂的疾病管理挑战。（剩余8771字）