嘌呤受体与阿尔茨海默病及靶向药物的研究进展

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[Abstract]Alzheimerdisease（AD）isaneurodegenerativedisordercharacterizedbygradualonsetandprogressivedeterioration.Tepurinergicsignalingpathwayiscrucialforneurotransmissionandneuromodulation，andisimplicatedinthepathogenic mechanisms of AD，encompassing amyloid β -protein（Aβ）accumulation，aberrant phosphorylation of Tau protein，oxidative stress （ROS），andpersistenteuroiflammatio.ActivationofspecificpurinereceptorsanmelioratecognitivedefictsinADbysafeguadingneurons，eliinatingAβplaques，ndengagingiiammatorysposes.Ionofcertainpurinereceptorsamelioates rylossesinADbymtigatingeuronalsynaticplasticityimpaiment，decreasingAβdepositionexpeditingayloidprecursoprotein （APP）hydrolysis，andengagingininflmmatoryresponses.Thisarticleelucidatestheoleofpurinergicreceptorsinthepathological alterationsofADndviesteadvancementsintargeedaacologicalintervetions，iingtersightsndefereforAD treatment.

[Key words] Purinergic receptors；Alzheimer's disease；Amyloid β -protein；Targeted drugs

阿尔茨海默病（Alzheimerdisease，AD）是一种以进行性认知功能减退，并伴有情感障碍为主要临床表现的神经退行性疾病，又称老年性痴呆[1]。（剩余15834字）