新型脑靶向递送系统在中药制剂抗抑郁治疗中的应用进展
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[关键词］新型脑靶向递送系统；中药制剂；抗抑郁治疗；血脑屏障；生物利用度[中图分类号］R277.7 ［文献标志码］A [文章编号]0257-358X（2026）01-0093-10DOI： 10.16295/j.cnki.0257-358x.2026.01.018
Application Progress of Novel Brain-Targeted Delivery System in Antidepressant Treatment with Traditional Chinese Medicine Preparation
HUANG Liuxuan1，YU Bingjie²，GUO Dongjing1，TIAN Haoquan³，MA Ke1 （1.Shandong Universityof Traditional ChineseMedicine，Jinan250355，China；2.JinanBlood Supplyand Assurance Center，Jinan250o01，China；3.CollgeofRehabilitation Medicine，Shandong Universityof Traditional Chinese Medicine，Jinan 250355，China）
AbstractDepression，asamulti-dimensional mental disorder，ischaracterized byitscore clinical manifestations of persistent emotional regulation disorder，lack of motivation andcognitive function impairment.It hasbecomeoneof the mental health problems with the heaviest disease burden worldwide.Traditional Chinese medicine （TCM）preparation，with their unique advantages ofmultiple ingredients and multiple targets，have demonstrated significant potential in antidepressant. However，the complexity of the ingredients of TCM and the highly selective permeability of the bloodbrain barrier limit its targeted delivery to the brainandclinical transformation.Thenovel brain-targeteddelivery system significantly enhancesthebioavailability andbrain-specificcharacteristicsofactive ingredients in TCM.Thisarticle reviews theroleof TCM preparation inthe treatment of depresion and the influence of the blood-brain barrier in the treatment of depression.It focuses on discussng the latest research progress of nano-delivery system，targeted delivery system，sustainedreleasedeliverysystemand inhalation deliverysystem inenhancing thepermeabilityofthe blood-brain barrier，optimizing drug release kinetics and reducing adverse reactions.There are 9O references.
Keywordsnovel brain-targeted deliverysystem；traditional Chinese medicine preparations；antidepressant treatment;blood-brain barrier;bioavailability
抑郁症是以心境低落和绝望无助为特征的常见精神类疾病，具有高复发率、高自杀率和高病死率特征[1]。（剩余19165字）
