基于“土壅木郁"探讨胆汁酸-肠道菌群轴对肝内胆汁淤积症的影响

[中图分类号］R256.4 [文献标志码］A [文章编号]0257-358X（2026）01-0027-05

DOI：10.16295/j.cnki.0257-358x.2026.01.006

Exploration on Efect of Bile Acid-Intestinal Microbiota Axis on Intrahepatic Cholestasis Based on “Earth Congestion and Wood Stagnation"

WANG Wenxiu1，WANG Yujuan²，WANG Jiheng²，YU Lil 2 ，DUAN Xiaodong （1.TheFirst Clinical Medical Collegeof Shandong University of Traditional Chinese Medicine，Jinan 250014， China;2.Jinan Hospital of Guang'anmen Hospital，China Academy of Chinese Medical Sciences/Jinan Hospital ofTraditional Chinese Medicine，Jinan 25oO12，China）

AbstractIntrahepatic cholestasis isacommon liver system disease.The imbalance of the bile acid-intestinal microbiota axisis closely related to the occurrenceand developmentof intrahepatic cholestasis.“Earth congestion and wood stagnation”is a pathological process in which the spleen earth isobstructed and counterattacks theliver wood，leading to thestagnationof liver wood.It playsa significantrole in the pathogenesisof intrahepaticcholestasis.Intestinal microecological disorderandbileacid metabolism disorder areimportant manifestationsof“earth congestion and wood stagnation”.This article explores the relationship among“earth congestionandwood stagnation”，bile acid-intestinal microbiotaaxis imbalance，and intrahepatic cholestasis，and proposes that the bileacid-intestinal microbiota axiscan be intervened based on the“earth congestion and wood stagnation”theory to prevent and treat intrahepatic cholestasis，which providesa newideaforthe integrated prevention and treatmentof intrahepatic cholestasis with traditional Chinese and Western medicine.

Keywordsearth congestion and wood stagnation; bileacid metabolism；intestinal microflora；intrahepatic cholestasis

肝内胆汁淤积症（IC）是指因肝实质细胞和/或肝内胆管疾病引起的胆汁合成缺陷、排泌失常，以及胆管内胆汁流动的机械性或功能性障碍，继而使胆汁成分进入血液而导致的临床综合征，常见有胆汁淤积性肝病（CLD）、妊娠期肝内胆汁淤积症（ICP）以及遗传代谢相关的胆汁淤积等[1]。（剩余9704字）