非编码RNA对骨关节炎的调控机制及中药干预研究进展

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中图分类号R965 文献标志码A 文章编号 1001-0408（2025）14-1819-06

DOI 10.6039/j.issn.1001-0408.2025.14.23

ABSTRACTOsteoarthritis（OA）isachronicdegenerativediseasecharacterizedprimarilybythedegenerationofarticular cartilage，withitspathogenesisinvolvingamultifactorialinterplayofinflammatoryresponses，chondrocyteapoptosis，and extracelular matrix（ECM）degradation.Non-codingRNA（ncRNA）participatesintheoccurrenceanddevelopment ofOAthrough theirdiverseregulatorypathways，providingnewpotentialtargetsforitstreatment.Thispapersystematicallyelucidatesthe mechanisms of ncRNA[micro ncRNA（miR），circular ncRNA（circR），and long ncRNA（IncR）] in regulating OA，as welas the current research statusoftraditional Chinesemedicine（TCM）intervening inOAbymodulatingncRNA.Itisfoundthat ncRNA participateinthepathologicalprocesssofOAbyconstructingamulti-layeredregulatorynetwork：miRinhibitsthetranslationof keytargetgenesandregulate downstreamsignaling pathways；circRcanactas‘molecularsponges’tocompetitivelyabsorbmRs forindirectregulationaswellasdirectlymodulateprotein functions；IncRpoess both‘molecularsponge’capabilitesandthe abilityto ntervene directlyin pathways.Andrograpolide，Xinfengcapsulesandothers interveneintheOA process byregulating theexpressionof miR，forminga‘TCM-miR-downstreamresponsechain’，whichreduces the expresionof matrix-hydrolyzing enzymesandinibitsthesecretionof inflammatoryfactors；paeoniflorin，Ronginniantongformulaandothers interveneintheOA process byaffectingcircRandlncR，thereby forminga‘TCM-lncR/circR-miR-downstreamresponsechain’topromotechondrocyte proliferation and reduce ECM degradation.

KEYWORDSosteoarthritis；traditional Chinese medicine；compound formula；non-coding RNA；regulatory mechanism

骨关节炎（osteoarthritis，OA）是中医骨伤科常见病范畴，多因素交互作用使其病因复杂，病情缠绵难愈。（剩余15430字）