人工智能与群体药动学模型在器官移植术后个体化用药中的应用与展望

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ABSTRACTArtificial inteligence（AI）andpopulationpharmacokinetics（PPK）technologieshavedemonstratedsignificant potentialinthepersonalizedmedicationofimmunosuppressantsafterorgantransplantation，enablingprecisepredictionofdrug dosages.ThisarticleprovidesacomprehensivereviewoftheapplicationstatusofAIandPPKintheindividualizedadministration of immunosuppessntsafterorgan transplantation，focusesonmonitoringblooddrugconcentration，predictingeficacy/adverse reactions，andestablishingindividualizeddosingmodelsfororgantransplantrecipientsafterimmunosuppessntadministration，and analyzesandcomparestheappicationcharactersticsofdiferentmethodsindiferentorgantransplantpatientsaswellasthe integrationand futuredevelopmentofAIandPPKtechnologies.AIandPPKtechnologiescannotonlysignificantlyreducethe dependenceonhumanresources，butalsogreatlyimprovethelevelof individualizedtreatmentofimmunosuppresantsafterorgan transplantation，and reduce the discomfortand burdencausedby frequent bloodconcentrationmonitoring topatients.

KEYWORDSartificial intelligence；population pharmacokinetics；organ transplantation； indiviualized medication

器官移植是治疗多种终末期脏器疾病的重要手段。（剩余15037字）