中药调控NF-κB信号通路防治心肌梗死的研究进展

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中图分类号R965；R285 文献标志码A 文章编号 1001-0408（2025）14-1807-06

nOI 106030/iiccn 1001 040820251421

ABSTRACTMyocardialinfarction（MI）referstoanacuteclinicalsyndromeofmyocardialnecrosisduetopersistentischemia and hypoxia，resulting from the sharp reduction or interuption of coronary blood flow.Nuclear factor κB （NF- κB ）isthekey factorininducinginflammatorresponse，anditisinvolvedintheproductionofpro-inflammatoryfactorsandmyocardialcel apoptosis.This article systematically describes the molecular regulation mechanism of the NF- κB signaling pathway in MI，and reviewstherelatedresearchonthepreventionandtreatmentofMIthrough theregulationofthissignaling pathwaybyactive ingredientsandcompoundformulasfromtraditionalChinesemedicine（TCM）.IthasbeenfoundthatactiveingredientsfromTCM， such as ginsenoside Rg3 ，baicalein，curcumin，tanshinone IA ，gambogic acid，as well as compound formulas，including Qili qiangxincapsules，Yiqi huoxuedecoction，Lingbao huxindan，Danhong injection，Baoyuandecoctioncombinedwith Taohong siwudecoction，canimproveyocardial fibrosis，aleviate inflammatoryresponses，andinhibitcardiomyocyteapoptosisby suppressing the NF- ⋅κB signaling pathway. Thereby，they achieve the goal of preventing and treating MI.

KEYWORDSmyocardial infarction;NF- σκB ；traditional Chinese medicine；active ingredients；compound formula

心肌梗死（myocardialinfarction，MI）是一种全球发病率和死亡率均较高的疾病，全球每年约有700万人患此病[]。（剩余15630字）