高剂量艾普拉唑联合阿莫西林用于老年新发幽门螺杆菌感染患者的临床研究

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中图分类号R975 文献标志码A 文章编号 1001-0408（2025）14-1792-05

DOI 10.6039/j.issn.1001-0408.2025.14.18

ABSTRACTOBJECTIVEToevaluatetheeficacyandsafetyof high-doseilaprazolecombinedwithamoxiclinfornewly diagnosedelderlypatientswithHelicobacterpylori（Hp）infection，ndanalyzeindependentriskfactorsforfailureofHpinfection eradication treatmentMETHODSTotally2Ocasesof newlydiagnosedelderlypatientswithHpinfectioninXinxiangCentral Hospital fromAugust1，2021toDecember1，2024 wereselectedandrandomlydivided intocontrolgroupandstudygroup，with 100cases ineachgroup.Thecontrol groupwas treatedwithclasicquadrupletherapyregimen（Amoxicillncapsules+ Clarithromycintablets+Bismuthpotassumcitratetablets+Ilprazoleenteric-coatedtablets）.Thestudygroupwastreatedwithhig doseIaprazoleenteric-coatedtablets+Amoxicilincapsules.Allpatientsereadministeredmedicationforweeks.Hperadication ratesintetwogroups werecomparedusing intention-to-treat（ITT）and per-protocol（PP）analyses.Theincidenceof adverse reactionsinbothgroupswasalsorecorded.Themultiple-factorLogisticregressonanalysiswasusedtoidentifyindependentrisk factors for failure of Hp infectioneradication treatment.RESULTSIn ITT andPPanalyses，therewas no significant differenceof Hp eradication rates between the two groups P>0.05 ）.There was no significant difference in incidence of mild to moderate adverse reactions between the two groups （ ⋅P>0.05 ）.BMI ⩽18.5kg/m2 BMI>23.9kg/m2 ，rural residence，concomitant diabetes andconcomitant heart diseasewereidentified asindependent risk factors influencing the failure of Hp infection eradication treatment （ （P<0.05 ）. CONCLUSIONS The eficacy and safety of high-dose ilaprazole combined with amoxicilin are comparable to classic quadruple therapy regimen in treating newly diagnosed elderly patients with Hp infection. Independent risk factors influencing the failure of Hp infection eradication treatment include BMI ⩽18.5kg/m2 ，BMI >23.9kg/m2 ，rural residence， concomitant diabetesand concomitant heart disease.

KEYWORDS Helicobacter pylori；high-dose dual therapy; ilaprazole；amoxicillin；intention-to-treat；per-protocol；elderly patient

幽门螺杆菌Helicobacterpylori（简称"Hp"）是一种主要存在于人体胃部及十二指肠内的革兰氏阴性菌。（剩余10047字）