尼莫地平治疗蛛网膜下腔出血后症状性脑血管痉挛的效果分析

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[Abstract] Objective：To explore the efficacy and safety of Nimodipine in the treatment of symptomatic cerebral vasospasm （SCVS）after subarachnoid hemorhage （SAH）. Method： A total of 104 patients with SCVS after SAHtreated at People's Hospital of Ruijin Citybetween May 2O21and May2O24 were enrolled.Using stratified random sampling， the patients were divided into control group and experimental group， with 52 cases in each group. Both groups underwent interventional embolization and received symptomatic supportive care.The control group received postoperative 3H therapy （hemodilution，hypervolemia，and hypertension）， while the experimental group received intra-arterialperfusionofNimodipineinadditiontothe3Htherapy.Theclinicalefficacy，cerebralvascular [anterior cerebral artery （ACA），middle cerebralartery （MCA），posteriorcerebral artery （PCA）] blood flow velocity， neurological function （NIHSS score），prognosis [Glasgowoutcome scale （GOS）score]，and serum biochemical index levels [cystatin C （Cys-C）， CRP，IL-6] between the two groups were compared.Result： The total effctive rateof treatment in the experimental group was higher than that in the control group （ P <0.05）.After the treatment， the blood flow velocitiesofACA，MCAandPCA in the experimental group were lower than those inthe control group （ P <0.05）. After the treatment，the NIHSS score of the experimental group was lower than thatof the control group，andthe GOS score was higher than that of the control group （ P <0.05）.The levels ofCys-C，CRPand IL-6 in the experimental group were all lower than those in the control group （ P <0.05）. Conclusion： Intra-arterial perfusion of Nimodipine inthetreatmentof SCVS after SAHnotonly improves the treatment effectiverate，improves cerebral vascularblood flow velocity，neurological functionand prognosis，but also regulates serum biochemical index levels，reduces inflammation and enhances vascular protective effects，showing good therapeutic potential and safety.

[Keywords] Nimodipine Subarachnoid hemorrhage Cerebral vasospasm Blood flow velocity eurological function

First-author'saddress：DepartmentofNeurosurgery，People'sHospitalofRuijinCity，Ruijin

China

doi：10.3969/j.issn.1674-4985.2025.21.016

蛛网膜下腔出血（SAH）是一种严重的脑血管事件，通常由脑动脉瘤破裂引起，严重时可导致症状性脑血管痉挛（SCVS），后者是SAH后常见的并发症，发生在血管破裂后的几天至几周内[]。（剩余6580字）