帕利哌酮缓释片联合氯氮平对难治性精神分裂症患者认知功能及脑电图参数的影响

打开文本图片集

[Abstract]Objective：To investigate the clinical application effct ofcombined treatment withPaliperidone Extended-Release Tablets and Clozapine in patients with treatment-resistant schizophrenia （TRS）.Method： Sixtypatientswith TRSwho visitedthe Departmentof Psychiatryof the Third People'sHospitalofYichun from January1，2O21 to December31，2O23 were selectedand divided into the reference group （30 cases）and the treatment group （3O cases） by random sampling method.The reference group was treated with Clozapine， while the treatment group was treated withPaliperidone Extended-Release Tablets combined with Clozapine.Clinical effcacy，the positive and negativesyndrome scale （PANSS）scores，inflammatory factor levels，cognitive function， and electroencephalogram （EEG） parameters were compared between the two groups. Adverse reactions that occurred during treatment was recorded.Result： The total effective rate in the treatment group was 93.33% （28/30）， which was higher than 73.33% （22/30） in the reference group （ P <0.05）.After 3 months of treatment， the scores of each dimension of PANSS inboth groups decreased，and the scores of the treatment group were lower than those of the reference group （ P <0.05）; the levelsof TNF- α ，IL-6，and IL-2 in both groups decreased，and those in the treatment group were lower than those in the reference group （ P <0.05）; the scores of each dimension of the MATRICS consensuscognitive battery （MCCB）in both groups significantlyincreased，and those in thetreatment group were significantly higher than those in the reference group （ P <0.05）; the EEG parameters of both groups improved，and those in the treatment group were better than those in the reference group （ P <0.05）; during the treatment period，there wasno statisticallysignificant diference intheoccurrence of adversereactions between the two groups P>0.05 ）.Conclusion：Paliperidone Extended-Release Tablets combined with Clozapine can significantly improve clinical effect in treating TRS，aleviate psychiatric symptoms，reduce inflammatoryreactions， and improve cognitive function and brain function in patients.

[KeyWords] Treatment-resistant schizophrenia Clozapine Paliperidone Extended-Release Tablets Cognitive function EEG parameters

First-author'saddress：DepartmentofPsychiatry，theThirdPeople'sHospitalofYichun，Yichun 336000， China

doi：10.3969/j.issn.1674-4985.2025.21.008

精神分裂症（schizophrenia，SZ）是一种以患者基本个性的转变，思维、情感及行为的断裂，以及其精神活动与外界环境之间存在显著的失调为特征的精神障碍[]。（剩余5705字）