宫腔灌注粒细胞集落刺激因子用于慢性子宫内膜炎的效果

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[Abstract]Objective：To observe the effects of uterine infusion of granulocyte colony-stimulating factor （G-CSF）on endometrial thicknes，uterine artery pulsatility index （PI） and resistance index （RI）， CD138 and/or CD38 expresion positiverate，and endometrial micropolyps in patients with chronic endometritis，and to explore itstherapeutic effcacy.Method：Patients with chronic endometritis who visited the Department of Reproductive Health Outpatientof Jiangxi Maternal and Child Health Hospital from January to June 2O22 were selected，and they wererandomly divided into two groups.The 35 patients of observation group received Human Granulocyte Colony-Stimulating Factor Injection， 150μg/d for3days，while the 35 patients of control group received oral Doxycycline Hyclate Tablets， 200mg/d for14 days.Before and after treatment， endometrial biopsies were performed under hysteroscopy for CD38 and CD138 immunohistochemical staining. Transvaginal ultrasound was used to measure endometrial thickness，uterine artery PI and RI，the therapeutic effects of the two groups were compared. Result： Compared with the control group，the thickness of the endometrium in the observation group significantlyincreasedaftertreatment，andtheuterinearteryPIandRIsignificantlyecreased，withsatistically significant differences （ P <0.05）. The expression positive rates of CD138 and/or CD38 in both groups decreased after treatment，andtherate intheobservationgroup was lower than thatinthecontrolgroup，withstatisticallysignificant differences （ P <0.05）.The incidence of small endometrial polyps in both groups improved after treatment，but there was no statistically significant difference between the two groups（ P>0.05 ）.Conclusion：Uterine infusion of G-CSF demonstrates significant clinical eficacy in the treatmentof chronic endometritis，improving endometrial thickness and blood perfusion while reducing the expression of inflammatory markers.

[Keywords] Uterine infusion Granulocyte colony-stimulating factor Chronic endometritis CD38 CD138

First-author'saddress：Department of Reproductive Health，Jiangxi Maternal and Child Health Hospital，Nanchang33oo29，hina doi： 10.3969/j.issn.1674-4985.2025.21.002

慢性子宫内膜炎（chronicendometritis，CE）是指宫腔内膜受感染所致的慢性炎症反应性疾病，临床组织病理诊断为子宫内膜间质中浆细胞浸润，因其临床症状轻微或多无症状，又常常被混淆为盆腔炎性疾病、阴道炎等进行对症处理，在临床中常常被忽视[。（剩余8415字）