新疆沙棘活性物质对离体蛙心活动的影响及机制研究

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【中图分类号】R285 【文献标志码】A 【文章编号】1007-8517（2025）15-0021-06

DOI： 10.3969/j .issn.1007-8517.2025.15. zgmzmjyyzz202515006

Study on the Effects Mechanisms Active Substances from Sea Buckthorn ontheActivityInVitroFrogHearts

LI Xingyuan1ZHAOYapingWANG Shifeng*WANG YuzhouYUSUPU·Kaidiriye CollegeLife Geographic Sciences，Kashi University，Kashi 844OOO，China

Abstract：Theactivesubstances seabuckthornhavetheeffectsreducing myocardialcontractility protecting theheart. This articleusesseabuckthornfruitsfromtwosubspeciesthreeproductionareasin China，aswellasaseabuckthorn juice beverage，todetettetsods，lolstoyasieedsspiely；Adeef tivesubstanceontheisolatedfrogheart.Theresultsshowedthattheorderactivesubstancecontentfromhightolowwas：Chinese seabuckthorn（from Lvliang） > Central Asian seabuckthorn（from Ta County） > Central Asian seabuckthorn （from Kashgar City）; The inhibition rates water extract extract on frog heart contractility were 50.4% 77.0% ， 57.7% 74.8%， 53.3% （204号 55.3% ，respectively. The inhibition rate seabuckthorn beverage was 68.2% ， the difference was extremely significant （ P<0 O1）.Afteradingfourtypescardiacreceptorblockers，theefectseabuckthoextractonfrogheartalphabetareeptorssignificantly decreased，while the effect on M receptors Ca2+ channels did not change significantly. This indicates that the active substancesseabuckthorhavethefectreducing myocardialcontractility，whichisrelatedtoalphabetareceptosdoesnot directly act on M receptors Ca2+ channels.

words：seabuckthorn；Active substances；Detached frog heart；Blocking agent

沙棘（HippophaerhamnoidesL.）属于胡颓子科沙棘属，别名又叫醋柳果、醋刺柳、酸刺、黑刺、醋柳等，为小灌木或乔木，其茎、叶、花、果、籽均可入药，具有悠久的药用历史，是蒙古族、藏族习用药材，曾先后被《月王药诊》《四部医典》《晶珠本草》《蒙药正典》《中华人民共和国药典》等书记载[1]。（剩余8500字）