颗粒物暴露致肺损伤的代谢组学分析与中医药干预

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[中图分类号]R256.1 [文献标志码]A [文章编号]doi：10.3969/j.issn.1674-070X.2025.06.030

Metabolomics analysis of particulate matter exposure-induced lung injuries and intervention with Chinese medicine

LU Jun ⋅1，2 ，LIUChang'， LIU Ziyi’，HUANG Wenshuo'，CHEN Zhuo'，LU Fangguo1* 1.Scholof edicine，Hunan UniversityofChineseMedicine，ChngshaHunan4O2O8，China;2.ShoolofItegratedCinee and Western Medicine， Hunan University of Chinese Medicine， Changsha， Hunan 41O2O8，China

[Abstract]Asglobalenvironmental polutionintensifies，the healthimpactsofparticulatemater（PM） havegarnered significantatention.PMentersthelungsthroughtherespiratorytract，trigeringaseriesofpathologicalchangesandprofoundly afectinghuman metabolicprocesss.Thisreviewsummarizestheapplicationsof metabolomics technologyininvestigating lung injuriescausedbydiferentPMcategoriesandtheinterventionswithChinesemedicine，aiming touncoverpotentialbiomarkersof PM-induced lung damage and elucidatethe protective mechanisms of Chinese medicinethroughregulationof metabolic pathways. Bysyntheiingurrntresearchisvieidentifscriicalliitationsicdinghomogeneityiniosapleselectioiiicant variabilityinreseachocoesandcalengesidatainterpretatioFutureivestigaiosouldprioriteultiicsintated analysisplatforms，promotetheintegrationofmetabolomicswithChinesemedicine，therebyprovidingnovelperspectivesand methodologies for preventing and treating PM-induced lung injuries.

[Keywords]metabolomics;particulate matter; lung injury；metabolic pathway；biomarker

随着城市化和工业化的加速，颗粒物污染问题日益严重。（剩余16301字）