基于“虚-滞-积"动态演变探讨糖尿病肾病的病机与治疗

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[关键词]糖尿病肾病；虚-滞-积；动态演变；理论探讨；辨证论治 [中图分类号]R255.4 [文献标志码]A [文章编号]doi：10.3969/j.issn.1674-070X.2025.06.019

Pathogenesis and treatment of diabetic nephropathy based on the dynamic evolution of "deficiency-stagnation-accumulation"

YANG Yuehua， LIN Yan*

FirstTeachingHospitalofTinjinUniversityofTraditionalChineseedicineNationalClinicalResearchCenterforCinee MedicineAcupunctureand Moxibustion，Tianjin 3oo382，China

[Abstract]Diabetic nephropathyisacommon complication ofdiabetes melitus and belongs to thecategoryof wasting and thirstdisordersinTCM.Chinesemedicinehasuniqueeficacyinthetreatmentofdiabeticnephropathynditisiportntto clarifythediseasemechanismtoguideclinicaltreatmentTepathogenesisofdiabeticnephropathyisoftencharacterizedasa combinationofdeficiencyattherootandexcessinthemanifestationThetransformationpatternof“deficiency-stagnationaccumulation”corespondstothepathologicalbasisofthisdiseaseprogressingfrodeficiencytoexcessDiabeticnepropathy mainlyinvolvesdeficincofspenandidney，leadingtodisorderedqisagnatinginthemeridiansandcollteralsichtu results inaccumulationofvariouspathologicalproductsanddamagetocollterals.Thesefactorsleadthediseaseintoitsterminal stage.Intermsoftreatmentthrapeuticstrategiesshouldbetilordtothunderlyingpathogenesiswithsagedinterventiostat appropriatelycombinethemethodssuchastonifyingthesplenand kidney，regulatingqi，clearingheatanddrainingdampnes， circulatingbloodandtransformingstasis，andremovingtoxinsandeliminatingturbidityThiscomprehensiveaproachaimsto provide the optimal treatment plan for diabetic nephropathy.

[Keywords]diabeticnephropathy；deficiency-stagnation-accumulation；dynamicevolution；theoreticaldiscussion；pattern dentification and treatment

糖尿病肾病是糖尿病最常见的微血管并发症之一，其特征是蛋白尿、进行性肾功能损害及肾脏纤维化，最终进展至终末期肾病。（剩余10222字）