壮医莲花针拔罐逐瘀法对带状疱疹后神经痛小鼠 β -catenin、FZ8及炎症因子的影响

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[关键词]带状疱疹后神经痛；壮医莲花针拔罐逐瘀法；白细胞介素-18;肿瘤坏死因子 -α ;β-连环蛋白；Frizzled-8 [中图分类号]R245 [文献标志码]A [文章编号]doi：10.3969/j.issn.1674-070X.2025.06.007

Effects of Zhuang medicine Lotus Needle Cupping Stasis-Resolving Method on β⋅σβ⋅σβ⋅σβ -catenin， FZ8，and inflammatory factors in mice with postherpetic neuralgia

LAI Jingjing， LI Meikang*，HAN Haitao， LI Jie， HUA NG Jinming， TA N Lei， XU Jing， LUO Hong DepartmentofZhuangMedicineAcupuncture，TheFirstAfliatedHospitalofuangxi Universityof ChineseMedicineNanning Guangxi 530023， China

[Abstract]Objective Toinvestigate the effects of the Zhuang medicine Lotus Needle Cuppng Stasis-Resolving Method on behavioral changes and the expressions of β -catenin， Frizzled-8 （FZ8） and inflammatory factors in mice with postherpetic neuralgia （PHN）.MethodFortyKMmice wererandomlydividedintoa blank controlgroup （ontrol group），apostherpeticneuralgiagroup （PHN group）， a gabapentin group （JBPD group），anda Zhuang medicineLotus Needle Cupping and Stasis-Resolving group （ZY group），with1Omiceineachgroup.TePHmousemodelwasestablishedusingresiniferatoxinBehavioralchanges，includingpaw withdrawal treshold（PWandthermalwithdrawallatencyTWL）werebservedpost-interventionineachgroupofmice.EIA was used tomeasure the levels of interleukin-18 （IL-18） andtumor necrosis factor -α （TNF-α） in mouse serum，and immunohistochemistry and Western blot were used to measure the expressions of β -catenin and FZ8 factors in the spinal cord posteriorhom.ResultAftermodeling，comparedwiththeControl group，thePHNgroupshoweddecreasedPWTandincreasedTWL （ P： <0.05），indicatingsuessfulmodelestablshmentComparedwiththePHgoup，bothJBPDandZYgroupsshowedincreasedPWT on the 10th day of treatment （ P <0.05）and decreased TWLonthe 15th day of treatment （ P<0.05 ）.Compared with the JBPD group， the ZY group showed increased PWT and decreased TWL on the 25th day of treatment （ P- <0.05）. Compared with the Control group， the expressions of IL-18 and TNF- α increased in the PHN group （ PΣ <0.05）.Compared with the PHN group，the expressions of IL-18 and TNF- α decreased in the JBPD and ZY groups（ P* <0.05）.Compared with the Control group， the expressions of β -cateninand FZ8 increased in the PHN group （P

[Keywords] postherpeticneuralgia; Zhuang medicine Lotus Needle Cupping Stasis-Resolving Method;interleukin-18;tumor necrosis factor- α ： β -catenin;Frizzled-8

近年来，带状疱疹后神经痛（postherpetic neu-ralgia，PHN）成为一个日益受到关注的临床问题，主要表现为神经受损区产生自发痛、异常疼痛和痛觉过敏，严重影响了患者的生活质量1-2。（剩余11023字）