脑缺血再灌注不同阶段的损伤机制及中药干预作用

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[关键词]脑缺血再灌注；中药；中药单体；中药复方；发病机制；作用机制 [中图分类号]R255.2 [文献标志码]A [文章编号]doi：10.3969/j.issn.1674-070X.2025.06.029

Injury mechanisms at different stages of cerebral ischemia-reperfusion and the interventional effects of Chinese medicines

ZHOU Xin'，LI Lan'， FU Ziyu’， OUYANG Linqi'，HU Hua’， CHEN Zhen’， DENG Guiming I，2： ￥ 1.The First Hospital of Hunan University of Chinese Medicine，Changsha， Hunan 41Ooo7，China; 2.The Second Hospital of Hunan University of Chinese Medicine，Changsha， Hunan 41ooo5，China

[Abstract]Cerebralischemia-reperfusioninjury（CIRI），acommoncomplicationfollowingstroke，ischaracterizedbycomplex pathogenesisandpoorclinicalprognosis.CIRIcanbedividedintothreephases：acuteischemiaearlyreperfusion，andlate reperfusionEachphaseexhibitsdistinctyetinterconnectedinjurymechanismsthatcolectivelyacceleratediseaseprogession， ultimatelyleading toirreversiblebraindamage.Theacuteischemicphaseisdominatedbyenergymetabolismdysfunctioand calciumoverload;theearlyreperfusionphaseismarkedbysevereoxidativestressandinflammatoryresponses;whilethelate reperfusionphaseinvolvesferroptosisandimpairedneurogenesis，contributingtoieversiblebraintissedamage.Chinese medicines demonstratesuniqueadvantages intreating CIRIbyexertingsynergisticefectsthroughmultiplepathwaysandtargets， suchasantioxidantstress，inhibitinginflammatoryresponses，protectingmitochondrialfunction，andregulatingcalciumion homeostasis，therebycomprehensivelyameliorating thepathologicalprocessofCIRIThispapersystematicallyreviewstephased injurymechanismsofCRIandsummarizestheexperimentalresearchprogressofChinesemedicinesinterventionsinIIaiming to providenew insights for the mechanistic studyand clinical translation of Chinese medicines in treating CIRI.

[Keywords]cerebral ischemia-reperfusion;Chinese medicines; Chinese medicine monomer;Chinese medicinecompound; ）athogenesis;mechanism of action

脑缺血再灌注损伤（cerebral ischemia-reperfu-sion injury，CIRI）是指在缺血性脑卒中后，血流和氧气供应恢复，神经细胞结构和功能进一步受损的病理过程[]。（剩余17534字）