基于线粒体质量控制失衡探讨从“玄府-气液”论治膝骨关节炎

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本文引用：，．基于线粒体质量控制失衡探讨从“玄府-气液"论治膝骨关节炎[J].湖南中医药大学学报，2025，45（5）：950-955.

关键词]膝骨关节炎；线粒体质量控制；玄府-气液;慢性骨关节病；理论探讨 [中图分类号]R274.9 [文献标志码]A [文章编号]doi：10.3969/j.issn.1674-070X.2025.05.025

[Abstract]KneeOsteoarthritis （KOA）isaprevalentchronic jointdisorder，thepathogenesisof which iscloselyasociated withmitochondrialdysfunctionandtheimbalanceof"mysteriousmansion（thegatewaysofqiascending，descending，exitingand enteringinthebody）qiandfluids"inChineseMedicine.Thisstudyintegratesthemechanismofmitochondrialqualitycontrolwith the TCMtheoryof "mysterious mansion-qiandfluids"to proposeanoveltherapeuticappoach forKOA.Threecore TCMtreatment methodsare introduced：using pungent-dispersingmedicines toopen mysteriousmansion，eliminatingdampnessandunblocking collateralstosmothmysteriousmansion，andeploingtoifyingmethodtohancemysteriousmansionsfunction.Byrgulating theopeningandclosingoftheXuanFu，itpromotestheoperationofQi，bloodandbodyfluids，andthusimprovesmitocondrial function.Inthispaper，fromtheperspectiveofmitochondrialqualitycontrolimbalance，theintrinsicconnectionbetween mitochondrialfunctionandthetheoryof"mysteriousmansion-qiandfluidsisexploredindepth，soastoprovideamoresolid theoretical basis for the prevention and treatment of KOA.

[Keywords]kneeosteoarthritis；mitochondrialqualitycontrol；mysteriousmansion-qiandfluids；chronicosteoarticulai disease; theoretical discussion

膝骨关节炎（knee osteoarthritis，KOA）是一种渐进发生的慢性骨关节病，以退行性软骨病变和继发性骨质增生为特征，临床常表现为膝关节疼痛、僵硬、功能障碍I。（剩余12637字）