基于“阳微阴弦"理论探讨血管平滑肌细胞增殖与迁移在动脉粥样硬化中的作用

本文引用：.基于“阳微阴弦"理论探讨血管平滑肌细胞增殖与迁移在动脉粥样硬化中的作用[J].湖南中医药大学学报，2025，45（5）：933-938.

[关键词]动脉粥样硬化；血管平滑肌细胞；细胞增殖；细胞迁移；表型转化；阳微阴弦；胸痹心痛 [中图分类号]R256.2 [文献标志码]A [文章编号]doi：10.3969/j.issn.1674-070X.2025.05.022

[Abstract]Atherosclerosis （AS）isacomplexvasculardisease characterizedbylipiddepositionandtheaccumulatioof inflammatorycellwithinthearterialwall，oftenleadingtoadversecardiovascularandcerebrovascularevents.Inrecentyears， vascularsmoth musclecell（VSMC）phenotypicswitching，particularlytetransitionfromtheontractiletothesyntheticphenotype， hasbeenrecognizedasakeymechanism inASprogresionContractile VSMCsprimarilymaintainvasculartoneandstructural stability，werassthticVshitanedsreoryproiferative，ndgatoyapacitis，trebypromotingpatolical vascularremodeling.InTCMtheorythefunctionalcharacteristicsofcontractileVSMCscanbeanalogizedto"yang"，whilethe biosyntheticactivityofsytheticVMCscorespondsto"yin"，Tedynamictransformationbetweethephenotypescoresods，to acertainextent，withtheTCMpathogenetictheoryof"yangdeficiencyandyinexcess".Basedonthis，thestudyintegratesthe

TCMtheorywithmoderncelularandmolecularmechanismstoinvestigatetheroleofVSMCphenotypicswitchingintheAS pathogenesis.Aditionaly，itsystematicallyeviewsTCMherapeuticprinciplesandmethods，ndthemechanismsandmolecular targetsofvarioussingleherbalcompoundsandformulasinregulating VSMCphenotypicswitchingandinhibitingabnormal proiferationandmigration.Thisstudyaimstoprovidenewinsightsforboththeclinicalmanagementandfundamentalresearchof AS while offering a unique perspective on the role of VSMCs in AS from the standpoint of TCM.

[Keywords]atheroslerosis;vascularsmothmusclecels;cellproliferation；cell migration;phenotypicswitching;yang deficiency and yin excess; chest bi-impediment and cardiac pain

动脉粥样硬化（atherosclerosis，AS）是一种常见的血管疾病，其特征是动脉内膜下脂质沉积，伴随炎症细胞浸润和纤维帽形成，最终导致动脉壁增厚和硬化。（剩余12307字）