基于“肝主筋，肾主骨"理论辨证取穴温针灸联合膝痹方治疗膝骨关节炎的临床研究及模型化评价

打开文本图片集

本文引用：刘顺超，石昆，陈绍华.基于“肝主筋，肾主骨"理论辨证取穴温针灸联合膝痹方治疗膝骨关节炎的临床研究及模型化评价[J].湖南中医药大学学报，2025，45（5）：883-890.

1图分类号]R245 [文献标志码]B [文章编号]doi：10.3969/j.issn.1674-070X.2025.05.014

[Abstract]Objective To investigate the clinical eficacyof warmneedle moxibustionatselected acupoints from pattem identificationbasedonthetheoryof"livergoverssinewsandkidneygoversbones"combinedwiththeXibiFormulainthe treatmentofkneosteoarthris（KOA），aswellasitsimpactonserumiflammatoryfactorsandtoconstructaparmacodyamic model-basedevaluation.MethodsAtotalof97patientswithkneeosteoarthritis（KOA）admitedtoShanghaiChangningTianshan TraditionalChinese MedicineHospitalfrom September2O22to September2O24wereenroledinthisstudy.Thepatientswere randomlydividedintocontrol group（treatedwithwarmneedemoxibustionalone，n=49）andstudygroup（reatedwithacombination of warm needle moxibustion and the Xibi Formula， n=48 ），withbalanced baseline characteristics between the two groups.The Western OntarioandMcMaster UniversitiesOsteoarthritisIndex （WOMAC）scores，LequesneFunctionalAlgorithmIndexscores， TCM pattern scores， as well as serum levels of tumor necrosis factor- αα∝αααα （TNF- α ）and interleukins （IL），were compared between the twogroupsbeforeandaftertreatmentAnonlinearmixed-efectsmodelwasutilizedtoestablishatime-efectmodelforthe combinedtreatmentofwamnedlemoxibustionandXibiFormulainKOA.Themodelsgoodnessof-fitandparameterstability wereevaluated，anditspredictieperformancewasessedroughvisualizationandalysisasedonthefinalmodeltical time-efectcurvesforTCMpaternscoresundervariousbaselineconditions weresimulated.ResultsAftertreatment，thestudy groupexhibitedsignificantlyhighercureratesbasedonthe WMACscores，markedefectivenessrates，andoverallefectiveness rates based on the Lequesne scores compared to the control group （ Pe O.05）.After treatment，compared with the pre-treatment status， there was no statistically significant difference in fatigue and lassitude score in the control group （ P>0.05 ），while the scores of the study group decreased （ P 6 （ Pe ⋅1β ，and IL-6 compared to the control group （ P

[Keywords]kneeosteoarthritis;livergovernssinews;kidneygovernsbones;warmnedlemoxibustion;XibiFormula;in mmation response;pharmacodynamic model

膝骨关节炎（knee osteoarthritis，KOA）是一种常见的慢性退行性关节疾病，严重影响患者的生活质量。（剩余10192字）