教授从“伏毒致痹"探析奥沙利铂所致急性周围神经毒性

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本文引用：，.教授从“伏毒致痹"探析奥沙利铂所致急性周围神经毒性[J].湖南中医药大学学报，2025，45（5）：910-915.

[关键词］奥沙利铂；周围神经病变；神经毒性；伏毒；温阳通络散；名医经验 [中图分类号]R249 [文献标志码]A [文章编号]doi：10.3969/j.issn.1674-070X.2025.05.018

[Abstract]Oxaliplatinisathird-generation platinum drug，which is widelyusedindigestivetracttumors，anditsadverse reactionsaremostcommoninoxaliplatin-inducedperipheralneurotoxicity（OIPN），whichisclasifiedintotwotypes：acuteand chronic.cuteoxaliplatin-inducedperipheralneurotoxicity （AOIPN）isatransientneurotoxicitysymptomoccuring within24-48h afteroxaliplatininfusionhichisdominatedbysnsoryabnomalitiesthatafectspatientsqualtyoflifeandinsverecases， forcingthemtochangetheirtreatmentregimenandafectingsurvival.ProfesorLIULikunbelievesthathidentoxicityisthe causative factorofOP，whichisharacterizedbyimpedientblockingvesselsandcolateralsandstrongconcealmentdiis treatedbywarmingcoldanddampness，expelingtoxinsandremoving bloodstasis，andthecombinationofexternalwashingwith theself-draftedWenyang TongluoPowderhasaremarkabletherapeuticefectThispaperdiscussesthetreatmentofAOIPfrom thetheoryof"atenttoxicitycausingimpediment"，andatachesaclinicalrecordinodertoprovideideasfortheclinicaltreatet of AOIPN.

[Keywords]oxaliplatin；peripheral neuropathy；neurotoxicity；latent toxicity；Wenyang TongluoPowder；experienceof famous doctors

奥沙利钼所致周围神经毒性（oxaliplatin-inducedperipheral neuropathy，OIPN）表现为四肢末端感觉障碍，包括刺痛、麻木、冷或温暖的异常皮肤感觉[。（剩余10073字）