基于“脾肾互赞”理论探讨内质网应激在多囊卵巢综合征中的作用

本文引用：，.基于“脾肾互赞"理论探讨内质网应激在多囊卵巢综合征中的作用[J].湖南中医药大学学报，2025，45（5）：939-944.

[关键词]脾肾互赞；多囊卵巢综合征；内质网应激；未折叠蛋白质应答；补肾健脾法 [中图分类号]R271.1 [文献标志码]A [文章编号]doi：10.3969/j.issn.1674-070X.2025.05.023

[Abstract]Polycysticovarysyndrome （PCOS） is a common reproductive endocrine system disease，and its pathogenesis is not completelyclear.Endoplasmicreticulumstress （ERS）isinvovedintheoccurrenceanddevelopmentofPCOSthroughtheunfolded proteinresponsesignalingpathwayhichisoselyelatedtoteathologicalproceessuchasgraulosacellapoptosiseive androgenchroniciflammation，andisulinsistance（I）ERSexhbitsaualoleinprotetingcelsandpromotingpotosis.It sharesmechanisticsimilaritieswiththetheoryof"splen-kidneymutualpromotion"inChinesemedicine，whereinspleenand kidneysynergisticallymaintainhebodyhealthunderphysiologicalconditions，yetleadtomutualdamageandcontributetodisease progressionunderpathologicalstates.Splenandkidneydeficiencycanlead to intracelularenvironmentdisorder，andthusinduce ERS，thecontinuousactivationof which furtheraggravatesthemetabolicandreproductivedysfunctionof COS.Basedonthe theoryof"spleen-kidneymutualpromotion，thispaperexplorestheroleofERSinthepathogenesisofPCOS，inordertofindthe relationshipbetweenthetwoandtoexplorethemechanismbywhichthekidneytonifyingandspleen-strengtheningtherapeutic method alleviates PCOS through regulation ofERS，soas to provide new ideasand methodsforthetreatmentof PCOS.

[Keywords]spleen-kidney mutual promotion； polycysticovary syndrome; endoplasmicreticulum stress；unfoldedprotein response; tonifying kidney and strengthening spleen method

多囊卵巢综合征（polycystic ovary syndrome，PCOS）是一种常见的内分泌代谢紊乱性疾病，其病理特征包括高雄激素血症、排卵功能障碍及卵巢多囊样改变等。（剩余14825字）