从“脾失散精、毒邪内生"理论与线粒体自噬介导铁死亡探讨溃疡性结肠炎病机

本文引用：，.从“脾失散精、毒邪内生”理论与线粒体自噬介导铁死亡探讨溃疡性结肠炎病机[J].湖南中医药大学学报，2025，45（4）：748-752.

[关键词]溃疡性结肠炎；脾失散精；毒邪内生；线粒体自噬；铁死亡；氧化应激 [中图分类号]R25 [文献标志码]A [文章编号]doi：10.3969/j.issn.1674-070X.2025.04.025

[Abstract] Chinese medicine posits that "spleen deficiency leading to dysfunctionof esence distributionandendogenous toxicpathogens"isthepathogenesisofhonicareaichisalogoustolerativecolitis（UCcusedbymitopagiated feroptosis.BasedontheTCMtheoryof"analogyandimagery"，"spleendeficiencyleadingtodysfunctionofessencedistribution" corespondstocelularenergydeficiencyesultingfrommitophagy，while"endogenoustoxicpathogens"areakintoinflammatory reactiontrigeredbyferoptosis.Therefore，thispaperaims toexplorethemechanismofactionofTCMinregulatingmitophagymediatedferroptosisforthetreatmentofUC，basedonthetheoryof"spleen deficiencyleading todysfunctionof essence distributionandendogenoustoxicpathogens".Furthermore，ithasprovidedanin-depthanalysisoftheinterplayamong mitophagy ferroptosis，and UC，offering areliable basisand noveltherapeutic insights forthe modernizationof TCMresearch.

[Keywords]ulcerativecolitis；spleendeficiencyleadingtodysfunctionofesencedistribution;endogenoustoxicpathogens; mitophagy； ferroptosis; oxidative stress

溃疡性结肠炎（ulcerativecolitis，UC）是一种病变主要累及结肠、直肠黏膜和黏膜下层的慢性非特异性炎症，属于病因不明的炎症性肠病范畴，临床上主要表现为腹泻、黏液脓血便、腹痛等。（剩余10763字）